PDBe 5e8y

X-ray diffraction
2.05Å resolution

TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN (E431A,R433A,E485A,K488A,R493A,R495A) IN COMPLEX WITH STAUROSPORINE

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TGF-beta receptor type-2 Chain: A
Molecule details ›
Chain: A
Length: 316 amino acids
Theoretical weight: 35.84 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P37173 (Residues: 237-549; Coverage: 57%)
Gene name: TGFBR2
Sequence domains: Protein tyrosine kinase

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 64.9Å b: 75.97Å c: 74.98Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.197 0.227
Expression system: Spodoptera frugiperda