PDBe 5dy5

X-ray diffraction
1.95Å resolution

Crystal structure of human Sirt2 in complex with a SirReal probe fragment

Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
NAD-dependent protein deacetylase sirtuin-2 Chain: A
Molecule details ›
Chain: A
Length: 304 amino acids
Theoretical weight: 34.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q8IXJ6 (Residues: 56-356; Coverage: 77%)
Gene names: SIR2L, SIR2L2, SIRT2
Sequence domains: Sir2 family

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2
Unit cell:
a: 98.15Å b: 53.36Å c: 83.59Å
α: 90° β: 114.01° γ: 90°
R R work R free
0.191 0.19 0.205
Expression system: Escherichia coli BL21(DE3)