PDBe 5dxt

X-ray diffraction
2.25Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Chain: A
Molecule details ›
Chain: A
Length: 962 amino acids
Theoretical weight: 112.05 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P42336 (Residues: 107-1068; Coverage: 90%)
Gene name: PIK3CA
Sequence domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 58.507Å b: 133.672Å c: 141.339Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.227 0.262
Expression system: Spodoptera frugiperda