PDBe 5dkc

X-ray diffraction
1.6Å resolution

Crystal structure of the bromodomain of human BRM (SMARCA2) in complex with PFI-3 chemical probe

Released:
Source organism: Homo sapiens
Entry authors: Tallant C, Owen DR, Gerstenberger BS, Fedorov O, Savitsky P, Nunez-Alonso G, Fonseca M, Krojer T, Filippakopoulos P, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Muller S, Knapp S

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Probable global transcription activator SNF2L2 Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 14.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51531 (Residues: 1373-1511; Coverage: 8%)
  • Best match: P51531-2 (Residues: 1373-1493)
Gene names: BAF190B, BRM, SMARCA2, SNF2A, SNF2L2

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: R3
Unit cell:
a: 74.424Å b: 74.424Å c: 89.856Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.195 0.194 0.211
Expression system: Escherichia coli