PDBe 5dh3

X-ray diffraction
2.47Å resolution

Crystal structure of MST2 in complex with XMU-MP-1

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 3 36kDa subunit Chains: A, B
Molecule details ›
Chains: A, B
Length: 315 amino acids
Theoretical weight: 35.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13188 (Residues: 15-313; Coverage: 61%)
Gene names: KRS1, MST2, STK3
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: C2221
Unit cell:
a: 89.871Å b: 98.462Å c: 166.771Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.211 0.247
Expression system: Escherichia coli BL21(DE3)