PDBe 5daf

X-ray diffraction
2.37Å resolution

Crystal Structure of Human KEAP1 BTB Domain in Complex with Small Molecule TX64063

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kelch-like ECH-associated protein 1 Chain: A
Molecule details ›
Chain: A
Length: 140 amino acids
Theoretical weight: 15.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14145 (Residues: 49-182; Coverage: 22%)
Gene names: INRF2, KEAP1, KIAA0132, KLHL19
Sequence domains: BTB/POZ domain
Structure domains: Potassium Channel Kv1.1; Chain A

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P3112
Unit cell:
a: 42.449Å b: 42.449Å c: 134.044Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.204 0.202 0.233
Expression system: Escherichia coli BL21(DE3)