PDBe 5d9s

X-ray diffraction
1.87Å resolution

Structure of HLA-A2:01 with the 11-mer peptide F11V

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, A-2 alpha chain Chain: A
Molecule details ›
Chain: A
Length: 274 amino acids
Theoretical weight: 31.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01892 (Residues: 25-298; Coverage: 80%)
Gene names: HLA-A, HLAA
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Ubiquitin family protein Chain: C
Molecule details ›
Chain: C
Length: 11 amino acids
Theoretical weight: 1.36 KDa
Source organism: Toxoplasma gondii
UniProt:
  • Canonical: S7UWA0 (Residues: 16-26; Coverage: 3%)
Gene name: TGGT1_223680

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P21
Unit cell:
a: 53.33Å b: 80.238Å c: 56.855Å
α: 90° β: 113.17° γ: 90°
R-values:
R R work R free
0.191 0.19 0.223
Expression system: Escherichia coli