PDBe 5d7p

X-ray diffraction
1.76Å resolution

Crystal structure of human Sirt2 in complex with ADPR and EX-243

Released:
Source organism: Homo sapiens
Primary publication:
Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking.
OpenAccess logo Acta Crystallogr F Struct Biol Commun 71 1498-510 (2015)
PMID: 26625292

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NAD-dependent protein deacetylase sirtuin-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 304 amino acids
Theoretical weight: 34.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IXJ6 (Residues: 56-356; Coverage: 77%)
Gene names: SIR2L, SIR2L2, SIRT2
Sequence domains: Sir2 family

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P212121
Unit cell:
a: 76.496Å b: 77.578Å c: 114.206Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.19 0.224
Expression system: Escherichia coli