PDBe 5d7n

X-ray diffraction
1.83Å resolution

Crystal structure of human Sirt3 at an improved resolution

Source organism: Homo sapiens
Primary publication:
Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking.
OpenAccess logo Acta Crystallogr F Struct Biol Commun 71 1498-510 (2015)
PMID: 26625292

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
NAD-dependent protein deacetylase sirtuin-3, mitochondrial Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 281 amino acids
Theoretical weight: 31.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9NTG7 (Residues: 118-395; Coverage: 70%)
Gene names: SIR2L3, SIRT3
Sequence domains: Sir2 family
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P21
Unit cell:
a: 84.99Å b: 143.85Å c: 89.46Å
α: 90° β: 116.33° γ: 90°
R R work R free
0.176 0.175 0.203
Expression system: Escherichia coli