PDBe 5c40

X-ray diffraction
1.5Å resolution

Crystal structure of human ribokinase in complex with AMPPCP in P21 spacegroup

Released:
Source organism: Homo sapiens
Entry authors: Park J, Chakrabarti J, Singh B, Gupta RS, Junop MS

Function and Biology Details

Reaction catalysed:
ATP + D-ribose = ADP + D-ribose 5-phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribokinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 330 amino acids
Theoretical weight: 35.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H477 (Residues: 1-322; Coverage: 100%)
Gene names: RBKS, RBSK
Sequence domains: pfkB family carbohydrate kinase
Structure domains: UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P21
Unit cell:
a: 45.79Å b: 72.42Å c: 92.75Å
α: 90° β: 90.43° γ: 90°
R-values:
R R work R free
0.129 0.127 0.181
Expression system: Escherichia coli BL21(DE3)