PDBe 5c27

X-ray diffraction
2.15Å resolution

Crystal structure of SYK in complex with compound 2

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein kinase SYK Chain: A
Molecule details ›
Chain: A
Length: 299 amino acids
Theoretical weight: 35.04 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P43405 (Residues: 343-635; Coverage: 46%)
Gene name: SYK
Sequence domains: Protein tyrosine kinase
Structure domains:
GLU-VAL-TYR-GLU-SER Chain: D
Molecule details ›
Chain: D
Length: 5 amino acids
Theoretical weight: 626 Da
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 39.879Å b: 84.875Å c: 89.592Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.177 0.225
Expression system: Spodoptera frugiperda