PDBe 5c0b

X-ray diffraction
2.03Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
HLA class I histocompatibility antigen, A-2 alpha chain Chains: A, F
Molecule details ›
Chains: A, F
Length: 275 amino acids
Theoretical weight: 31.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01892 (Residues: 25-299; Coverage: 81%)
Gene names: HLA-A, HLAA
Sequence domains:
Structure domains:
Beta-2-microglobulin Chains: B, G
Molecule details ›
Chains: B, G
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Marker peptide Chains: C, H
Molecule details ›
Chains: C, H
Length: 10 amino acids
Theoretical weight: 1.18 KDa
Source organism: Homo sapiens
Expression system: Not provided
T cell receptor alpha constant; T cell receptor alpha variable 12-3 Chains: D, I
Molecule details ›
Chains: D, I
Length: 199 amino acids
Theoretical weight: 22.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01848 (Residues: 1-89; Coverage: 64%)
  • Canonical: A0A0B4J271 (Residues: 25-113; Coverage: 96%)
  • nullnull
Gene names: TCRA, TRAC, TRAV12-3
Structure domains: Immunoglobulins
T cell receptor beta constant 2; T cell receptor beta variable 12-4 Chains: E, J
Molecule details ›
Chains: E, J
Length: 247 amino acids
Theoretical weight: 28.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A5B9 (Residues: 1-129; Coverage: 73%)
  • Canonical: A0A0B4J2E0 (Residues: 20-115; Coverage: 100%)
  • nullnull
Gene names: TCRBC2, TRBC2, TRBV12-4
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P1
Unit cell:
a: 43.94Å b: 100.28Å c: 122.44Å
α: 96.98° β: 98.05° γ: 96.53°
R-values:
R R work R free
0.194 0.192 0.231
Expression systems:
  • Escherichia coli
  • Not provided