PDBe 5bxf

X-ray diffraction
2.85Å resolution

Apo FcRn Structure at pH 4.5

Released:
Source organism: Homo sapiens
Entry authors: Nam H-J, Taha M

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
IgG receptor FcRn large subunit p51 Chains: A, C
Molecule details ›
Chains: A, C
Length: 300 amino acids
Theoretical weight: 33.39 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: P55899 (Residues: 1-290; Coverage: 78%)
Gene names: FCGRT, FCRN
Sequence domains:
Structure domains:
Beta-2-microglobulin Chains: B, D
Molecule details ›
Chains: B, D
Length: 119 amino acids
Theoretical weight: 13.73 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: P61769 (Residues: 1-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P21
Unit cell:
a: 42.183Å b: 77.583Å c: 140.546Å
α: 90° β: 93.6° γ: 90°
R-values:
R R work R free
0.242 0.237 0.314
Expression system: unidentified baculovirus