PDBe 5brz

X-ray diffraction
2.62Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Melanoma-associated antigen 3 Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 1.04 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P43357 (Residues: 168-176; Coverage: 3%)
Gene names: MAGE3, MAGEA3
T cell receptor beta variable 5-1; T cell receptor beta constant 2 Chain: E
Molecule details ›
Chain: E
Length: 241 amino acids
Theoretical weight: 27.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A5B9 (Residues: 1-128; Coverage: 72%)
  • Canonical: A0A578 (Residues: 21-113; Coverage: 99%)
  • nullnull
Gene names: TCRBC2, TCRBV5S1A1T, TRBC2, TRBV5-1
Sequence domains:
Structure domains: Immunoglobulins
T cell receptor alpha variable 21; T cell receptor alpha constant Chain: D
Molecule details ›
Chain: D
Length: 197 amino acids
Theoretical weight: 21.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01848 (Residues: 2-12, 13-82; Coverage: 58%)
  • Canonical: A0A0B4J279 (Residues: 21-112; Coverage: 99%)
  • nullnull
Gene names: TCRA, TRAC, TRAV21
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins
HLA class I histocompatibility antigen, A-1 alpha chain Chain: A
Molecule details ›
Chain: A
Length: 275 amino acids
Theoretical weight: 31.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P30443 (Residues: 25-298; Coverage: 80%)
Gene names: HLA-A, HLAA
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: C2
Unit cell:
a: 173.59Å b: 47.5Å c: 119.25Å
α: 90° β: 109.12° γ: 90°
R-values:
R R work R free
0.197 0.193 0.268
Expression systems:
  • Escherichia coli
  • Not provided