PDBe 5bon

X-ray diffraction
1.8Å resolution

Function and Biology Details

Reaction catalysed:
A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleotide triphosphate diphosphatase NUDT15 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 164 amino acids
Theoretical weight: 18.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NV35 (Residues: 1-164; Coverage: 100%)
Gene names: MTH2, NUDT15
Sequence domains: NUDIX domain
Structure domains: Nucleoside Triphosphate Pyrophosphohydrolase

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P1
Unit cell:
a: 60.83Å b: 71.676Å c: 82.768Å
α: 90.07° β: 90.04° γ: 73.08°
R-values:
R R work R free
0.194 0.193 0.22
Expression system: Escherichia coli BL21(DE3)