PDBe 5bjt

X-ray diffraction
3.2Å resolution

Crystal structure of human FcRn with a peptide inhibitor at multiple sites

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
monomeric
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
IgG receptor FcRn large subunit p51 Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 267 amino acids
Theoretical weight: 29.72 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P55899 (Residues: 24-290; Coverage: 78%)
Gene names: FCGRT, FCRN
Sequence domains:
Structure domains:
Beta-2-microglobulin Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
peptide inhibitor Chains: P, Q, R, S, T, U, V
Molecule details ›
Chains: P, Q, R, S, T, U, V
Length: 19 amino acids
Theoretical weight: 2.16 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: I222
Unit cell:
a: 104.917Å b: 176.152Å c: 245.515Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.257 0.252 0.339
Expression systems:
  • Cricetulus griseus
  • Not provided