PDBe 5b2l

X-ray diffraction
2.1Å resolution

A crucial role of Cys218 in the stabilization of an unprecedented auto-inhibition form of MAP2K7


Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Dual specificity mitogen-activated protein kinase kinase 7 Chain: A
Molecule details ›
Chain: A
Length: 324 amino acids
Theoretical weight: 36.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: O14733 (Residues: 102-419; Coverage: 76%)
Gene names: JNKK2, MAP2K7, MEK7, MKK7, PRKMK7, SKK4
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: P212121
Unit cell:
a: 56.985Å b: 65.445Å c: 88.458Å
α: 90° β: 90° γ: 90°
R R work R free
0.196 0.192 0.264
Expression system: Escherichia coli