PDBe 5awa

X-ray diffraction
2.2Å resolution

Crystal structure of human TLR8 in complex with MB-568

Source organism: Homo sapiens
Entry authors: Tanji H, Ohto U, Shimizu T

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Toll-like receptor 8 Chain: A
Molecule details ›
Chain: A
Length: 811 amino acids
Theoretical weight: 92.84 KDa
Source organism: Homo sapiens
Expression system: Drosophila
  • Canonical: Q9NR97 (Residues: 27-827; Coverage: 79%)
Gene names: TLR8, UNQ249/PRO286
Sequence domains:
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: C2
Unit cell:
a: 139.057Å b: 102.379Å c: 72.077Å
α: 90° β: 106.82° γ: 90°
R R work R free
0.22 0.217 0.286
Expression system: Drosophila