› 5a6i

X-ray diffraction
1.86Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 13.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:
Ligand TCW 1 x TCW
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: I222
Unit cell:
a: 42.484Å b: 62.547Å c: 84.684Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.197 0.271
Expression system: Escherichia coli

Quick links

Citations

34 review citations

Transthyretin Amyloid Cardiomyopathy: JACC State-of-the-Art Review.
Ruberg et al. (2019)
33 more

2 mentions without citation

Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity.
Sant'Anna et al. (2016)
1 more