› 4z9q

X-ray diffraction
2.23Å resolution

Crystal structure of OXA-58 with disordered active site

Released:
DOI: 10.2210/pdb4z9q/pdb
PDB entry 4z9q coloured by chain, front view.
PDB entry 4z9q coloured by chain, side view.
PDB entry 4z9q coloured by chain, top view.
Source organism: Acinetobacter baumannii ACICU
Entry authors: Pratap S, Gill PK, Golemi-Kotra D, Kumar P

Function and Biology Details

Reaction catalysed: 
A beta-lactam + H(2)O = a substituted beta-amino acid
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-lactamase Chain: A
Molecule details ›
Chain: A
Length: 280 amino acids
Theoretical weight: 31.5 KDa
Source organism: Acinetobacter baumannii ACICU
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0A182DW26 (Residues: 1-280; Coverage: 100%)
Gene names: ACICU_p0019, ACICU_p0024
Sequence domains: Penicillin binding protein transpeptidase domain
Structure domains: DD-peptidase/beta-lactamase superfamily

Ligands and Environments

No bound ligands
1 modified residue:
Ligand KCX 1 x KCX

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR-H
Spacegroup: P21
Unit cell:
a: 37.36Å b: 39.79Å c: 72.09Å
α: 90° β: 91.2° γ: 90°
R-values:
R R work R free
0.195 0.192 0.253
Expression system: Escherichia coli BL21(DE3)

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