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Crystal structure of human SPT16 Mid-AID/H3-H4 tetramer FACT Histone complex

Source organism: Homo sapiens
Biochemical function: protein heterodimerization activity
Biological process: protein localization to CENP-A containing chromatin
Cellular component: nucleosome

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF15511
Domain description: Centromere kinetochore component CENP-T histone fold
Occurring in:
  1. Histone H4
The deposited structure of PDB entry 4z2m contains 2 copies of Pfam domain PF15511 (Centromere kinetochore component CENP-T histone fold) in Histone H4. Showing 1 copy in chain C [auth H].

PF00125
Domain description: Core histone H2A/H2B/H3/H4
Occurring in:
  1. Histone H3.1
The deposited structure of PDB entry 4z2m contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H3.1. Showing 1 copy in chain B [auth G].

PF08512
Domain description: Histone chaperone Rttp106-like, middle domain
Occurring in:
  1. FACT complex subunit SPT16
The deposited structure of PDB entry 4z2m contains 1 copy of Pfam domain PF08512 (Histone chaperone Rttp106-like, middle domain) in FACT complex subunit SPT16. Showing 1 copy in chain A [auth B].

InterPro InterPro annotations
IPR001951
Domain description: Histone H4
Occurring in:
  1. Histone H4
IPR000164
Domain description: Histone H3/CENP-A
Occurring in:
  1. Histone H3.1
IPR009072
Domain description: Histone-fold
Occurring in:
  1. Histone H3.1
  2. Histone H4
IPR035425
Domain description: CENP-T/Histone H4, histone fold
Occurring in:
  1. Histone H4
IPR004823
Domain description: TATA box binding protein associated factor (TAF), histone-like fold domain
Occurring in:
  1. Histone H4
IPR019809
Domain description: Histone H4, conserved site
Occurring in:
  1. Histone H4
IPR007125
Domain description: Histone H2A/H2B/H3
Occurring in:
  1. Histone H3.1
IPR013719
Domain description: Histone chaperone RTT106/FACT complex subunit SPT16-like, middle domain
Occurring in:
  1. FACT complex subunit SPT16
IPR013953
Domain description: FACT complex subunit Spt16 domain
Occurring in:
  1. FACT complex subunit SPT16
IPR011993
Domain description: PH-like domain superfamily
Occurring in:
  1. FACT complex subunit SPT16
IPR040258
Domain description: FACT complex subunit Spt16
Occurring in:
  1. FACT complex subunit SPT16

Structure domains

CATH CATH domains
1.10.20.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Histone, subunit A
Homology: Histone, subunit A
Occurring in:
  1. Histone H3.1
  2. Histone H4
The deposited structure of PDB entry 4z2m contains 2 copies of CATH domain 1.10.20.10 (Histone, subunit A) in Histone H3.1. Showing 1 copy in chain B [auth G].
The deposited structure of PDB entry 4z2m contains 2 copies of CATH domain 1.10.20.10 (Histone, subunit A) in Histone H4. Showing 1 copy in chain C [auth H].
2.30.29.30
Class: Mainly Beta
Architecture: Roll
Topology: PH-domain like
Homology: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Occurring in:
  1. FACT complex subunit SPT16
The deposited structure of PDB entry 4z2m contains 1 copy of CATH domain 2.30.29.30 (PH-domain like) in FACT complex subunit SPT16. Showing 1 copy in chain A [auth B].
2.30.29.150
Class: Mainly Beta
Architecture: Roll
Topology: PH-domain like
Homology: PH-domain like
Occurring in:
  1. FACT complex subunit SPT16
The deposited structure of PDB entry 4z2m contains 1 copy of CATH domain 2.30.29.150 (PH-domain like) in FACT complex subunit SPT16. Showing 1 copy in chain A [auth B].

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