Function and Biology

Crystal structure of TAF1 BD2 Bromodomain bound to a butyryllysine peptide

Source organism: Homo sapiens
Biochemical function: TBP-class protein binding
Biological process: transcription by RNA polymerase II
Cellular component: transcription factor TFIID complex

EC 2.7.11.1: Non-specific serine/threonine protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
  • A-kinase
  • AP50 kinase
  • ATP-protein transphosphorylase
  • Beta-IIPKC
  • Beta-adrenergic receptor kinase
  • CK-2
  • CKI
  • CKII
  • Calcium-dependent protein kinase C
  • Calcium/phospholipid-dependent protein kinase
  • Casein kinase
  • Casein kinase (phosphorylating)
  • Casein kinase 2
  • Casein kinase I
  • Casein kinase II
  • Cyclic AMP-dependent protein kinase
  • Cyclic AMP-dependent protein kinase A
  • Cyclic monophosphate-dependent protein kinase
  • Cyclic nucleotide-dependent protein kinase
  • Cyclin-dependent kinase
  • Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
  • Dsk1
  • Epsilon PKC
  • Glycogen synthase A kinase
  • Glycogen synthase a kinase
  • Glycogen synthase kinase
  • HIPK2
  • Hpr kinase
  • Hydroxyalkyl-protein kinase
  • M phase-specific cdc2 kinase
  • MAPK
  • Mitogen-activated S6 kinase
  • Mitogen-activated protein kinase
  • P82 kinase
  • PKA
  • PKC
  • Phosphorylase B kinase kinase
  • Phosphorylase b kinase kinase
  • Phosphorylase b kinase kinase
  • Protein glutamyl kinase
  • Protein kinase (phosphorylating)
  • Protein kinase A
  • Protein kinase CK2
  • Protein kinase p58
  • Protein phosphokinase
  • Protein serine kinase
  • Protein serine-threonine kinase
  • Protein-aspartyl kinase
  • Protein-cysteine kinase
  • Protein-serine kinase
  • Prp4 protein kinase
  • Raf kinase
  • Raf-1
  • Ribosomal S6 protein kinase
  • Ribosomal protein S6 kinase II
  • STK32
  • Serine kinase
  • Serine protein kinase
  • Serine(threonine) protein kinase
  • Serine-specific protein kinase
  • Serine/threonine protein kinase
  • T-antigen kinase
  • Threonine-specific protein kinase
  • Twitchin kinase
  • Type-2 casein kinase
  • WEE1Hu
  • Wee 1-like kinase
  • Wee-kinase
  • cAMP-dependent protein kinase
  • cAMP-dependent protein kinase A
  • cGMP-dependent protein kinase

EC 2.3.1.48: Histone acetyltransferase

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Systematic name:
Acetyl-CoA:[protein]-L-lysine acetyltransferase
Alternative Name(s):
  • Acetyl-CoA:histone acetyltransferase
  • Histone acetokinase
  • Histone acetylase
  • Histone transacetylase
  • Lysine acetyltransferase
  • Nucleosome-histone acetyltransferase
  • Protein lysine acetyltransferase

Sequence family

Pfam Protein family (Pfam)
PF00439
Domain description: Bromodomain
Occurring in:
  1. Transcription initiation factor TFIID subunit 1
The deposited structure of PDB entry 4yym contains 2 copies of Pfam domain PF00439 (Bromodomain) in Transcription initiation factor TFIID subunit 1. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR001487
Domain description: Bromodomain
Occurring in:
  1. Transcription initiation factor TFIID subunit 1
IPR036427
Domain description: Bromodomain-like superfamily
Occurring in:
  1. Transcription initiation factor TFIID subunit 1
IPR018359
Domain description: Bromodomain, conserved site
Occurring in:
  1. Transcription initiation factor TFIID subunit 1
IPR040240
Domain description: Transcription initiation factor TFIID subunit 1
Occurring in:
  1. Transcription initiation factor TFIID subunit 1

Structure domain

CATH CATH domain
1.20.920.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Histone Acetyltransferase; Chain A
Homology: Bromodomain-like
Occurring in:
  1. Transcription initiation factor TFIID subunit 1
The deposited structure of PDB entry 4yym contains 2 copies of CATH domain 1.20.920.10 (Histone Acetyltransferase; Chain A) in Transcription initiation factor TFIID subunit 1. Showing 1 copy in chain B.