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Structure of S-adenosyl-L-homocysteine hydrolase

Source organism: Homo sapiens
Biochemical function: hydrolase activity
Biological process: S-adenosylmethionine cycle
Cellular component: extracellular exosome

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF05221
Domain description: S-adenosyl-L-homocysteine hydrolase
Occurring in:
  1. Adenosylhomocysteinase
The deposited structure of PDB entry 4yvf contains 4 copies of Pfam domain PF05221 (S-adenosyl-L-homocysteine hydrolase) in Adenosylhomocysteinase. Showing 2 copies in chain A.

PF00670
Domain description: S-adenosyl-L-homocysteine hydrolase, NAD binding domain
Occurring in:
  1. Adenosylhomocysteinase
The deposited structure of PDB entry 4yvf contains 2 copies of Pfam domain PF00670 (S-adenosyl-L-homocysteine hydrolase, NAD binding domain) in Adenosylhomocysteinase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000043
Domain description: Adenosylhomocysteinase-like
Occurring in:
  1. Adenosylhomocysteinase
IPR020082
Domain description: S-adenosyl-L-homocysteine hydrolase, conserved site
Occurring in:
  1. Adenosylhomocysteinase
IPR042172
Domain description: Adenosylhomocysteinase-like superfamily
Occurring in:
  1. Adenosylhomocysteinase
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. Adenosylhomocysteinase
IPR015878
Domain description: S-adenosyl-L-homocysteine hydrolase, NAD binding domain
Occurring in:
  1. Adenosylhomocysteinase

Structure domains

CATH CATH domains
3.40.50.1480
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Adenosylhomocysteinase-like
Occurring in:
  1. Adenosylhomocysteinase
The deposited structure of PDB entry 4yvf contains 2 copies of CATH domain 3.40.50.1480 (Rossmann fold) in Adenosylhomocysteinase. Showing 1 copy in chain A.
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. Adenosylhomocysteinase
The deposited structure of PDB entry 4yvf contains 2 copies of CATH domain 3.40.50.720 (Rossmann fold) in Adenosylhomocysteinase. Showing 1 copy in chain A.

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