PDBe 4yl3

X-ray diffraction
1.41Å resolution

Function and Biology Details

Reaction catalysed:
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Prostaglandin E synthase Chain: A
Molecule details ›
Chain: A
Length: 148 amino acids
Theoretical weight: 16.69 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: O14684 (Residues: 5-152; Coverage: 97%)
Gene names: MGST1L1, MPGES1, PGES, PIG12, PTGES
Sequence domains: MAPEG family

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: R3
Unit cell:
a: 76.434Å b: 76.434Å c: 123.264Å
α: 90° β: 90° γ: 120°
R R work R free
0.167 0.166 0.183
Expression system: Spodoptera frugiperda