Function and Biology

Crystal structure of C-terminal modified Tau peptide-hybrid 126B with 14-3-3sigma

Source organism: Homo sapiens
Biochemical function: protein sequestering activity
Biological process: negative regulation of stem cell proliferation
Cellular component: extracellular exosome

Sequence family

Pfam Protein family (Pfam)
PF00244
Domain description: 14-3-3 protein
Occurring in:
  1. 14-3-3 protein sigma
The deposited structure of PDB entry 4y5i contains 2 copies of Pfam domain PF00244 (14-3-3 protein) in 14-3-3 protein sigma. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000308
Domain description: 14-3-3 protein
Occurring in:
  1. 14-3-3 protein sigma
IPR023410
Domain description: 14-3-3 domain
Occurring in:
  1. 14-3-3 protein sigma
IPR036815
Domain description: 14-3-3 domain superfamily
Occurring in:
  1. 14-3-3 protein sigma
IPR023409
Domain description: 14-3-3 protein, conserved site
Occurring in:
  1. 14-3-3 protein sigma

Structure domain

CATH CATH domain
1.20.190.20
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Delta-Endotoxin; domain 1
Homology: 14-3-3 domain
Occurring in:
  1. 14-3-3 protein sigma
The deposited structure of PDB entry 4y5i contains 2 copies of CATH domain 1.20.190.20 (Delta-Endotoxin; domain 1) in 14-3-3 protein sigma. Showing 1 copy in chain B.