› 4y3k

X-ray diffraction
2.2Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184883 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serpin A12 Chains: A, B
Molecule details ›
Chains: A, B
Length: 414 amino acids
Theoretical weight: 47.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8IW75 (Residues: 22-414; Coverage: 100%)
Gene name: SERPINA12
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 5 x SO4
Ligand EDO 7 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: C2
Unit cell:
a: 132.959Å b: 151.353Å c: 61.602Å
α: 90° β: 98.43° γ: 90°
R-values:
R R work R free
0.188 0.186 0.219
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Review: Vaspin (SERPINA12) Expression and Function in Endocrine Cells.
Kurowska et al. (2021)
2 more