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Crystal structure of C-terminal modified Tau peptide-hybrid 201D with 14-3-3sigma

X-ray diffraction
1.8Å resolution
PDB entry 4y3b coloured by chain, front view.
PDB entry 4y3b coloured by chain, side view.
PDB entry 4y3b coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Microtubule-associated protein tau and 14-3-3 protein sigma
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Multimeric state: hetero tetramer
Accessible surface area: 23461.68 Å2
Buried surface area: 4099.38 Å2
Dissociation area: 1,028.2 Å2
Dissociation energy (ΔGdiss): 1.58 kcal/mol
Dissociation entropy (TΔSdiss): 13.09 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-145399

Macromolecules

14-3-3 protein sigma
Chains: A, B
Length: 236 amino acids
Theoretical weight: 26.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P31947 (Residues: 1-231; Coverage: 93%)
Gene names: HME1, SFN
Pfam: 14-3-3 protein
InterPro:
CATH: 14-3-3 domain
14-3-3 protein sigma in PDB entry 4y3b, assembly 1, front view.
14-3-3 protein sigma in PDB entry 4y3b, assembly 1, side view.
14-3-3 protein sigma in PDB entry 4y3b, assembly 1, top view.
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Microtubule-associated protein tau
Chains: C, D
Length: 7 amino acids
Theoretical weight: 852 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10636 (Residues: 528-534; Coverage: 1%)
Gene names: MAPT, MAPTL, MTBT1, TAU
Microtubule-associated protein tau in PDB entry 4y3b, assembly 1, front view.
Microtubule-associated protein tau in PDB entry 4y3b, assembly 1, side view.
Microtubule-associated protein tau in PDB entry 4y3b, assembly 1, top view.
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