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Crystal Structure of the Human Factor VIII C2 Domain in Complex with Murine 3E6 Inhibitory Antibody

X-ray diffraction
2.61Å resolution
PDB entry 4xzu coloured by chain, front view.
PDB entry 4xzu coloured by chain, side view.
PDB entry 4xzu coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Factor VIIIa light chain and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero trimer
Accessible surface area: 25861.54 Å2
Buried surface area: 5112.21 Å2
Dissociation area: 644.29 Å2
Dissociation energy (ΔGdiss): -5.63 kcal/mol
Dissociation entropy (TΔSdiss): 12.38 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-208209
Assembly 2 (preferred)
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Assembly Name: Factor VIIIa light chain and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero trimer
Accessible surface area: 25400.4 Å2
Buried surface area: 4565.77 Å2
Dissociation area: 635.09 Å2
Dissociation energy (ΔGdiss): -4.43 kcal/mol
Dissociation entropy (TΔSdiss): 12.35 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-208209

Macromolecules

3E6 antibody Fab heavy chain
Chains: A, E
Length: 219 amino acids
Theoretical weight: 23.54 KDa
Source organism: Mus musculus
InterPro:
CATH: Immunoglobulins
3E6 antibody Fab heavy chain in PDB entry 4xzu, assembly 2, front view.
3E6 antibody Fab heavy chain in PDB entry 4xzu, assembly 2, side view.
3E6 antibody Fab heavy chain in PDB entry 4xzu, assembly 2, top view.
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3E6 antibody Fab light chain
Chains: B, F
Length: 213 amino acids
Theoretical weight: 23.29 KDa
Source organism: Mus musculus
InterPro:
CATH: Immunoglobulins
3E6 antibody Fab light chain in PDB entry 4xzu, assembly 2, front view.
3E6 antibody Fab light chain in PDB entry 4xzu, assembly 2, side view.
3E6 antibody Fab light chain in PDB entry 4xzu, assembly 2, top view.
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Factor VIIIa light chain
Chains: G, M
Length: 154 amino acids
Theoretical weight: 17.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00451 (Residues: 2193-2346; Coverage: 7%)
Gene names: F8, F8C
Pfam: F5/8 type C domain
InterPro:
CATH: Galactose-binding domain-like
Factor VIIIa light chain in PDB entry 4xzu, assembly 2, front view.
Factor VIIIa light chain in PDB entry 4xzu, assembly 2, side view.
Factor VIIIa light chain in PDB entry 4xzu, assembly 2, top view.
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