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Human platelet phosphofructokinase in an R-state in complex with ADP and F6P, crystal form I

X-ray diffraction
2.67Å resolution
PDB entry 4xz2 coloured by chain, front view.
PDB entry 4xz2 coloured by chain, side view.
PDB entry 4xz2 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 6-phosphofructokinase, P4 homotetramer
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Multimeric state: homo tetramer
Accessible surface area: 104000.83 Å2
Buried surface area: 18406.75 Å2
Dissociation area: 1,398.76 Å2
Dissociation energy (ΔGdiss): -6.5 kcal/mol
Dissociation entropy (TΔSdiss): 16.58 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-169633
Complex Portal ID: CPX-1999

Macromolecules

ATP-dependent 6-phosphofructokinase, platelet type
Chains: A, B, C, D
Length: 761 amino acids
Theoretical weight: 83.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q01813 (Residues: 26-762; Coverage: 94%)
Gene names: PFKF, PFKP
Pfam: Phosphofructokinase
InterPro:
ATP-dependent 6-phosphofructokinase, platelet type in PDB entry 4xz2, assembly 1, front view.
ATP-dependent 6-phosphofructokinase, platelet type in PDB entry 4xz2, assembly 1, side view.
ATP-dependent 6-phosphofructokinase, platelet type in PDB entry 4xz2, assembly 1, top view.
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