Function and Biology

The complex structure of Timeless_PAB and PARP-1_catalytic domain

Source organism: Homo sapiens
Biochemical function: NAD+ ADP-ribosyltransferase activity
Biological process: not assigned
Cellular component: not assigned

EC 2.4.2.30: NAD(+) ADP-ribosyltransferase

Reaction catalysed:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
Systematic name:
NAD(+):poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase
Alternative Name(s):
  • ADP-ribosyltransferase (polymerizing)
  • NAD(+):poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase
  • NAD(+):poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase
  • Poly(ADP-ribose) synthase
  • Poly(ADP-ribose) synthetase
  • Poly(ADP-ribose)polymerase
  • Poly(adenosine diphosphate ribose) polymerase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF05029
Domain description: Timeless PAB domain
Occurring in:
  1. Protein timeless homolog
The deposited structure of PDB entry 4xhu contains 2 copies of Pfam domain PF05029 (Timeless PAB domain) in Protein timeless homolog. Showing 1 copy in chain D [auth B].

PF00644
Domain description: Poly(ADP-ribose) polymerase catalytic domain
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
The deposited structure of PDB entry 4xhu contains 2 copies of Pfam domain PF00644 (Poly(ADP-ribose) polymerase catalytic domain) in Poly [ADP-ribose] polymerase 1, processed C-terminus. Showing 1 copy in chain C [auth A].

PF02877
Domain description: Poly(ADP-ribose) polymerase, regulatory domain
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
The deposited structure of PDB entry 4xhu contains 2 copies of Pfam domain PF02877 (Poly(ADP-ribose) polymerase, regulatory domain) in Poly [ADP-ribose] polymerase 1, processed C-terminus. Showing 1 copy in chain C [auth A].

InterPro InterPro annotations
IPR012317
Domain description: Poly(ADP-ribose) polymerase, catalytic domain
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
IPR004102
Domain description: Poly(ADP-ribose) polymerase, regulatory domain
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
IPR036616
Domain description: Poly(ADP-ribose) polymerase, regulatory domain superfamily
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
IPR044998
Domain description: Timeless
Occurring in:
  1. Protein timeless homolog
IPR007725
Domain description: Timeless, C-terminal
Occurring in:
  1. Protein timeless homolog

Structure domains

CATH CATH domains
3.90.228.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Phosphoenolpyruvate Carboxykinase; domain 3
Homology: Phosphoenolpyruvate Carboxykinase; domain 3
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
The deposited structure of PDB entry 4xhu contains 2 copies of CATH domain 3.90.228.10 (Phosphoenolpyruvate Carboxykinase; domain 3) in Poly [ADP-ribose] polymerase 1, processed C-terminus. Showing 1 copy in chain C [auth A].
1.20.142.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Poly(ADP-ribose) Polymerase; domain 1
Homology: Poly(ADP-ribose) polymerase, regulatory domain
Occurring in:
  1. Poly [ADP-ribose] polymerase 1, processed C-terminus
The deposited structure of PDB entry 4xhu contains 2 copies of CATH domain 1.20.142.10 (Poly(ADP-ribose) Polymerase; domain 1) in Poly [ADP-ribose] polymerase 1, processed C-terminus. Showing 1 copy in chain C [auth A].