› 4wsr

X-ray diffraction
2.5Å resolution

The crystal structure of hemagglutinin form A/chicken/New York/14677-13/1998

Released:
DOI: 10.2210/pdb4wsr/pdb
PDB entry 4wsr coloured by chain, front view.
PDB entry 4wsr coloured by chain, side view.
PDB entry 4wsr coloured by chain, top view.
Source organism: Influenza A virus (A/chicken/New York/14677-13/1998(H6N2))
Primary publication:
Structure and receptor binding preferences of recombinant hemagglutinins from avian and human H6 and H10 influenza A virus subtypes.
Yang H, Carney PJ, Chang JC, Villanueva JM, Stevens J
J Virol 89 4612-23 (2015)
PMID: 25673707

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170844 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Hemagglutinin HA2 chain Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 514 amino acids
Theoretical weight: 57.87 KDa
Source organism: Influenza A virus (A/chicken/New York/14677-13/1998(H6N2))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q0A3A5 (Residues: 17-522; Coverage: 89%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 9 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2
Unit cell:
a: 252.545Å b: 134.822Å c: 123.093Å
α: 90° β: 113.23° γ: 90°
R-values:
R R work R free
0.212 0.21 0.246
Expression system: Trichoplusia ni

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Citations

7 review citations

Structural insights into the design of novel anti-influenza therapies.
Wu et al. (2018)
6 more

2 mentions without citation

Unraveling virus relationships by structure-based phylogenetic classification.
Ng et al. (2020)
1 more