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Crystal structure of oxaloacetate and NADH bound MDH2

X-ray diffraction
2.5Å resolution
PDB entry 4wlo coloured by chain, front view.
PDB entry 4wlo coloured by chain, side view.
PDB entry 4wlo coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Malate dehydrogenase, mitochondrial
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Multimeric state: homo tetramer
Accessible surface area: 43761.78 Å2
Buried surface area: 14096.36 Å2
Dissociation area: 3,924.14 Å2
Dissociation energy (ΔGdiss): 27.06 kcal/mol
Dissociation entropy (TΔSdiss): 41.9 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-154208

Macromolecules

Malate dehydrogenase, mitochondrial
Chains: A, B, C, D
Length: 340 amino acids
Theoretical weight: 35.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P40926 (Residues: 20-338; Coverage: 94%)
Gene name: MDH2
Pfam:
InterPro:
CATH:
Malate dehydrogenase, mitochondrial in PDB entry 4wlo, assembly 1, front view.
Malate dehydrogenase, mitochondrial in PDB entry 4wlo, assembly 1, side view.
Malate dehydrogenase, mitochondrial in PDB entry 4wlo, assembly 1, top view.
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