› 4wf5

X-ray diffraction
1.45Å resolution

Function and Biology Details

Reaction catalysed: 
2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol
Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-101384 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thiol:disulfide interchange protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 189 amino acids
Theoretical weight: 21.16 KDa
Source organism: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0A0H2UL03 (Residues: 1-189; Coverage: 100%)
Sequence domains: DSBA-like thioredoxin domain
Structure domains: Glutaredoxin

Ligands and Environments

4 bound ligands:
Ligand WF4 2 x WF4
Ligand CU 1 x CU
Ligand GOL 1 x GOL
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: C2
Unit cell:
a: 118.246Å b: 63.401Å c: 74.402Å
α: 90° β: 126.19° γ: 90°
R-values:
R R work R free
0.162 0.16 0.196

Quick links

Citations

8 review citations

Thinking Outside the Box-Novel Antibacterials To Tackle the Resistance Crisis.
Lakemeyer et al. (2018)
7 more