PDBe 4v11

X-ray diffraction
1.95Å resolution

Structure of Synaptotagmin-1 with SV2A peptide phosphorylated at Thr84

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Synaptotagmin-1 Chain: A
Molecule details ›
Chain: A
Length: 150 amino acids
Theoretical weight: 17.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P21579 (Residues: 273-422; Coverage: 36%)
Gene names: SVP65, SYT, SYT1
Sequence domains: C2 domain
Synaptic vesicle glycoprotein 2A Chain: B
Molecule details ›
Chain: B
Length: 10 amino acids
Theoretical weight: 1.16 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q7L0J3 (Residues: 81-90; Coverage: 1%)
Gene names: KIAA0736, PSEC0174, SV2A

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21
Unit cell:
a: 46.049Å b: 41.432Å c: 48.014Å
α: 90° β: 96.59° γ: 90°
R-values:
R R work R free
0.153 0.151 0.196
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided