› 4ufq

X-ray diffraction
1.45Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-102735 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hyaluronidase Chains: A, B
Molecule details ›
Chains: A, B
Length: 217 amino acids
Theoretical weight: 21.75 KDa
Source organism: Streptomyces koganeiensis
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A0U2E2J7 (Residues: 31-247; Coverage: 100%)
Sequence domains: Hyaluronidase protein (HylP)

Ligands and Environments

5 bound ligands:
Ligand SO4 5 x SO4
Ligand NA 5 x NA
Ligand CL 1 x CL
Ligand PEG 5 x PEG
Ligand GOL 2 x GOL
1 modified residue:
Ligand MSE 2 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: R32
Unit cell:
a: 66.884Å b: 66.884Å c: 483.942Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.151 0.15 0.174
Expression system: Escherichia coli

Quick links

Citations

5 citation in other articles

Engineered Bacteria Enhance Immunotherapy and Targeted Therapy through Stromal Remodeling of Tumors.
Thomas et al. (2022)
4 more

1 mention without citation

In Vivo Evaluation of a New Recombinant Hyaluronidase to Improve Gene Electro-Transfer Protocols for DNA-Based Drug Delivery against Cancer.
De Robertis et al. (2018)