4u52 › Citations

Structural basis for the inhibition of the eukaryotic ribosome.

Garreau de Loubresse N, Prokhorova I, Holtkamp W, Rodnina MV, Yusupova G, Yusupov M
Nature 513 517-22 (2014)
Related entries: 4u3m, 4u3n, 4u3u, 4u4n, 4u4o, 4u4q, 4u4r, 4u4u, 4u4y, 4u4z, 4u50, 4u51, 4u53, 4u55, 4u56, 4u6f

Cited: 249 times
EuropePMC logo PMID: 25209664

Abstract

The ribosome is a molecular machine responsible for protein synthesis and a major target for small-molecule inhibitors. Compared to the wealth of structural information available on ribosome-targeting antibiotics in bacteria, our understanding of the binding mode of ribosome inhibitors in eukaryotes is currently limited. Here we used X-ray crystallography to determine 16 high-resolution structures of 80S ribosomes from Saccharomyces cerevisiae in complexes with 12 eukaryote-specific and 4 broad-spectrum inhibitors. All inhibitors were found associated with messenger RNA and transfer RNA binding sites. In combination with kinetic experiments, the structures suggest a model for the action of cycloheximide and lactimidomycin, which explains why lactimidomycin, the larger compound, specifically targets the first elongation cycle. The study defines common principles of targeting and resistance, provides insights into translation inhibitor mode of action and reveals the structural determinants responsible for species selectivity which could guide future drug development.

Reviews - 4u52 mentioned but not cited (1)

  1. Inhibition of the Eukaryotic 80S Ribosome as a Potential Anticancer Therapy: A Structural Perspective. Pellegrino S, Terrosu S, Yusupova G, Yusupov M. Cancers (Basel) 13 4392 (2021)

Articles - 4u52 mentioned but not cited (2)

  1. Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A. McClary B, Zinshteyn B, Meyer M, Jouanneau M, Pellegrino S, Yusupova G, Schuller A, Reyes JCP, Lu J, Guo Z, Ayinde S, Luo C, Dang Y, Romo D, Yusupov M, Green R, Liu JO. Cell Chem Biol 24 605-613.e5 (2017)
  2. Archetypal transcriptional blocks underpin yeast gene regulation in response to changes in growth conditions. Talavera D, Kershaw CJ, Costello JL, Castelli LM, Rowe W, Sims PFG, Ashe MP, Grant CM, Pavitt GD, Hubbard SJ. Sci Rep 8 7949 (2018)


Reviews citing this publication (46)

  1. Non-AUG translation: a new start for protein synthesis in eukaryotes. Kearse MG, Wilusz JE. Genes Dev 31 1717-1731 (2017)
  2. Cryo-EM: A Unique Tool for the Visualization of Macromolecular Complexity. Nogales E, Scheres SH. Mol Cell 58 677-689 (2015)
  3. Toxicology of deoxynivalenol and its acetylated and modified forms. Payros D, Alassane-Kpembi I, Pierron A, Loiseau N, Pinton P, Oswald IP. Arch Toxicol 90 2931-2957 (2016)
  4. How Macrolide Antibiotics Work. Vázquez-Laslop N, Mankin AS. Trends Biochem Sci 43 668-684 (2018)
  5. Translatome profiling: methods for genome-scale analysis of mRNA translation. King HA, Gerber AP. Brief Funct Genomics 15 22-31 (2016)
  6. Impact of two mycotoxins deoxynivalenol and fumonisin on pig intestinal health. Pierron A, Alassane-Kpembi I, Oswald IP. Porcine Health Manag 2 21 (2016)
  7. Revisiting the Closed-Loop Model and the Nature of mRNA 5'-3' Communication. Vicens Q, Kieft JS, Rissland OS. Mol Cell 72 805-812 (2018)
  8. The Growing Toolbox for Protein Synthesis Studies. Iwasaki S, Ingolia NT. Trends Biochem Sci 42 612-624 (2017)
  9. Ribosomal stress-surveillance: three pathways is a magic number. Vind AC, Genzor AV, Bekker-Jensen S. Nucleic Acids Res 48 10648-10661 (2020)
  10. Trichothecenes in Cereal Grains - An Update. Foroud NA, Baines D, Gagkaeva TY, Thakor N, Badea A, Steiner B, Bürstmayr M, Bürstmayr H. Toxins (Basel) 11 E634 (2019)
  11. The Mechanisms of Action of Ribosome-Targeting Peptide Antibiotics. Polikanov YS, Aleksashin NA, Beckert B, Wilson DN. Front Mol Biosci 5 48 (2018)
  12. Structural insights into ribosome translocation. Ling C, Ermolenko DN. Wiley Interdiscip Rev RNA 7 620-636 (2016)
  13. Modified Fusarium Mycotoxins in Cereals and Their Products-Metabolism, Occurrence, and Toxicity: An Updated Review. Bryła M, Waśkiewicz A, Ksieniewicz-Woźniak E, Szymczyk K, Jędrzejczak R. Molecules 23 E963 (2018)
  14. The impact of in silico screening in the discovery of novel and safer drug candidates. Rognan D. Pharmacol Ther 175 47-66 (2017)
  15. Protein X-ray Crystallography and Drug Discovery. Maveyraud L, Mourey L. Molecules 25 E1030 (2020)
  16. Blast from the Past: Reassessing Forgotten Translation Inhibitors, Antibiotic Selectivity, and Resistance Mechanisms to Aid Drug Development. Arenz S, Wilson DN. Mol Cell 61 3-14 (2016)
  17. Two chaperones locked in an embrace: structure and function of the ribosome-associated complex RAC. Zhang Y, Sinning I, Rospert S. Nat Struct Mol Biol 24 611-619 (2017)
  18. Emerging Role of Eukaryote Ribosomes in Translational Control. Dalla Venezia N, Vincent A, Marcel V, Catez F, Diaz JJ. Int J Mol Sci 20 E1226 (2019)
  19. The relationship between the structure and toxicity of aminoglycoside antibiotics. Jospe-Kaufman M, Siomin L, Fridman M. Bioorg Med Chem Lett 30 127218 (2020)
  20. Targeting the Human 80S Ribosome in Cancer: From Structure to Function and Drug Design for Innovative Adjuvant Therapeutic Strategies. Gilles A, Frechin L, Natchiar K, Biondani G, Loeffelholz OV, Holvec S, Malaval JL, Winum JY, Klaholz BP, Peyron JF. Cells 9 E629 (2020)
  21. Trichothecenes: immunomodulatory effects, mechanisms, and anti-cancer potential. Wu Q, Wang X, Nepovimova E, Miron A, Liu Q, Wang Y, Su D, Yang H, Li L, Kuca K. Arch Toxicol 91 3737-3785 (2017)
  22. Recent Advances in the Development of Antineoplastic Agents Derived from Natural Products. Trendowski M. Drugs 75 1993-2016 (2015)
  23. Drug repurposing approach to combating coronavirus: Potential drugs and drug targets. Xu J, Xue Y, Zhou R, Shi PY, Li H, Zhou J. Med Res Rev 41 1375-1426 (2021)
  24. Along the Central Dogma-Controlling Gene Expression with Small Molecules. Schneider-Poetsch T, Yoshida M. Annu Rev Biochem 87 391-420 (2018)
  25. A Quick Guide to Small-Molecule Inhibitors of Eukaryotic Protein Synthesis. Dmitriev SE, Vladimirov DO, Lashkevich KA. Biochemistry (Mosc) 85 1389-1421 (2020)
  26. Therapeutic Opportunities in Eukaryotic Translation. Chu J, Pelletier J. Cold Spring Harb Perspect Biol 10 (2018)
  27. Crystal structure of eukaryotic ribosome and its complexes with inhibitors. Yusupova G, Yusupov M. Philos Trans R Soc Lond B Biol Sci 372 20160184 (2017)
  28. Ribosome Profiling as a Tool to Decipher Viral Complexity. Stern-Ginossar N, Ingolia NT. Annu Rev Virol 2 335-349 (2015)
  29. New Insights into Ribosome Structure and Function. Jobe A, Liu Z, Gutierrez-Vargas C, Frank J. Cold Spring Harb Perspect Biol 11 a032615 (2019)
  30. Structural Heterogeneities of the Ribosome: New Frontiers and Opportunities for Cryo-EM. Poitevin F, Kushner A, Li X, Dao Duc K. Molecules 25 E4262 (2020)
  31. Structural Insights into tRNA Dynamics on the Ribosome. Agirrezabala X, Valle M. Int J Mol Sci 16 9866-9895 (2015)
  32. Leading edge: emerging drug, cell, and gene therapies for junctional epidermolysis bullosa. Keith AR, Twaroski K, Ebens CL, Tolar J. Expert Opin Biol Ther 20 911-923 (2020)
  33. Microbial Inhibition of Fusarium Pathogens and Biological Modification of Trichothecenes in Cereal Grains. Wachowska U, Packa D, Wiwart M. Toxins (Basel) 9 E408 (2017)
  34. Viral Short ORFs and Their Possible Functions. Finkel Y, Stern-Ginossar N, Schwartz M. Proteomics 18 e1700255 (2018)
  35. Toxicodynamics of Mycotoxins in the Framework of Food Risk Assessment-An In Silico Perspective. Dellafiora L, Dall'Asta C, Galaverna G. Toxins (Basel) 10 E52 (2018)
  36. Cephalotaxus Alkaloids. Pérard-Viret J, Quteishat L, Alsalim R, Royer J, Dumas F. Alkaloids Chem Biol 78 205-352 (2017)
  37. A comprehensive coverage insurance for cells: revealing links between ribosome collisions, stress responses and mRNA surveillance. De S, Mühlemann O. RNA Biol 19 609-621 (2022)
  38. Multifaceted impact of trichothecene metabolites on plant-microbe interactions and human health. Kumari I, Ahmed M, Akhter Y. Appl Microbiol Biotechnol 100 5759-5771 (2016)
  39. The role of upstream open reading frames in translation regulation in the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii. Kaur C, Patankar S. Parasitology 148 1277-1287 (2021)
  40. Twelve-membered macrolactones: privileged scaffolds for the development of new therapeutics. Brzozowski RS, Wuest WM. Chem Biol Drug Des 89 169-191 (2017)
  41. A Review of Potential Therapeutic Strategies for COVID-19. Meng J, Li R, Zhang Z, Wang J, Huang Q, Nie D, Fan K, Guo W, Zhao Z, Han Z. Viruses 14 2346 (2022)
  42. Anticancer Activities and Mechanism of Action of Nagilactones, a Group of Terpenoid Lactones Isolated from Podocarpus Species. Bailly C. Nat Prod Bioprospect 10 367-375 (2020)
  43. Microbial detoxification of mycotoxins in food. Abraham N, Chan ETS, Zhou T, Seah SYK. Front Microbiol 13 957148 (2022)
  44. The Recurring Roles of Chlorine in Synthetic and Biological Studies of the Lissoclimides. Pak BS, Supantanapong N, Vanderwal CD. Acc Chem Res 54 1131-1142 (2021)
  45. Ribosome-Directed Therapies in Cancer. Temaj G, Chichiarelli S, Eufemi M, Altieri F, Hadziselimovic R, Farooqi AA, Yaylim I, Saso L. Biomedicines 10 2088 (2022)
  46. Structural Diversity and Biological Potential of Alkaloids from the Genus Hippeastrum, Amaryllidaceae: an Update. Tallini LR, Giordani RB, de Andrade JP, Bastida J, Zuanazzi JAS. Rev Bras Farmacogn 31 648-657 (2021)

Articles citing this publication (200)

  1. Structure of the human 80S ribosome. Khatter H, Myasnikov AG, Natchiar SK, Klaholz BP. Nature 520 640-645 (2015)
  2. The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity. Simsek D, Tiu GC, Flynn RA, Byeon GW, Leppek K, Xu AF, Chang HY, Barna M. Cell 169 1051-1065.e18 (2017)
  3. Visualization of chemical modifications in the human 80S ribosome structure. Natchiar SK, Myasnikov AG, Kratzat H, Hazemann I, Klaholz BP. Nature 551 472-477 (2017)
  4. Ribosome Collision Is Critical for Quality Control during No-Go Decay. Simms CL, Yan LL, Zaher HS. Mol Cell 68 361-373.e5 (2017)
  5. Ubiquitination of stalled ribosome triggers ribosome-associated quality control. Matsuo Y, Ikeuchi K, Saeki Y, Iwasaki S, Schmidt C, Udagawa T, Sato F, Tsuchiya H, Becker T, Tanaka K, Ingolia NT, Beckmann R, Inada T. Nat Commun 8 159 (2017)
  6. Understanding Biases in Ribosome Profiling Experiments Reveals Signatures of Translation Dynamics in Yeast. Hussmann JA, Patchett S, Johnson A, Sawyer S, Press WH. PLoS Genet 11 e1005732 (2015)
  7. DSSR: an integrated software tool for dissecting the spatial structure of RNA. Lu XJ, Bussemaker HJ, Olson WK. Nucleic Acids Res 43 e142 (2015)
  8. Risks to human and animal health related to the presence of deoxynivalenol and its acetylated and modified forms in food and feed. EFSA Panel on Contaminants in the Food Chain (CONTAM), Knutsen HK, Alexander J, Barregård L, Bignami M, Brüschweiler B, Ceccatelli S, Cottrill B, Dinovi M, Grasl-Kraupp B, Hogstrand C, Hoogenboom LR, Nebbia CS, Oswald IP, Petersen A, Rose M, Roudot AC, Schwerdtle T, Vleminckx C, Vollmer G, Wallace H, De Saeger S, Eriksen GS, Farmer P, Fremy JM, Gong YY, Gong YY, Meyer K, Naegeli H, Parent-Massin D, Rietjens I, van Egmond H, Altieri A, Eskola M, Gergelova P, Ramos Bordajandi L, Benkova B, Dörr B, Gkrillas A, Gustavsson N, van Manen M, Edler L. EFSA J 15 e04718 (2017)
  9. Demystifying traditional herbal medicine with modern approach. Li FS, Weng JK. Nat Plants 3 17109 (2017)
  10. High-Resolution Ribosome Profiling Defines Discrete Ribosome Elongation States and Translational Regulation during Cellular Stress. Wu CC, Zinshteyn B, Wehner KA, Green R. Mol Cell 73 959-970.e5 (2019)
  11. The mechanism of inhibition of protein synthesis by the proline-rich peptide oncocin. Roy RN, Lomakin IB, Gagnon MG, Steitz TA. Nat Struct Mol Biol 22 466-469 (2015)
  12. Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species. Topf U, Suppanz I, Samluk L, Wrobel L, Böser A, Sakowska P, Knapp B, Pietrzyk MK, Chacinska A, Warscheid B. Nat Commun 9 324 (2018)
  13. Aminoglycoside interactions and impacts on the eukaryotic ribosome. Prokhorova I, Altman RB, Djumagulov M, Shrestha JP, Urzhumtsev A, Ferguson A, Chang CT, Yusupov M, Blanchard SC, Yusupova G. Proc Natl Acad Sci U S A 114 E10899-E10908 (2017)
  14. Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition. Gagnon MG, Roy RN, Lomakin IB, Florin T, Mankin AS, Steitz TA. Nucleic Acids Res 44 2439-2450 (2016)
  15. Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD. Fang MY, Markmiller S, Vu AQ, Javaherian A, Dowdle WE, Jolivet P, Bushway PJ, Castello NA, Baral A, Chan MY, Linsley JW, Linsley D, Mercola M, Finkbeiner S, Lecuyer E, Lewcock JW, Yeo GW. Neuron 103 802-819.e11 (2019)
  16. CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts. Tabet R, Schaeffer L, Freyermuth F, Jambeau M, Workman M, Lee CZ, Lin CC, Jiang J, Jansen-West K, Abou-Hamdan H, Désaubry L, Gendron T, Petrucelli L, Martin F, Lagier-Tourenne C. Nat Commun 9 152 (2018)
  17. Stop codon context influences genome-wide stimulation of termination codon readthrough by aminoglycosides. Wangen JR, Green R. Elife 9 e52611 (2020)
  18. Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome. Schmidt C, Becker T, Heuer A, Braunger K, Shanmuganathan V, Pech M, Berninghausen O, Wilson DN, Beckmann R. Nucleic Acids Res 44 1944-1951 (2016)
  19. Integration of high-content screening and untargeted metabolomics for comprehensive functional annotation of natural product libraries. Kurita KL, Glassey E, Linington RG. Proc Natl Acad Sci U S A 112 11999-12004 (2015)
  20. Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis. Wong W, Bai XC, Sleebs BE, Triglia T, Brown A, Thompson JK, Jackson KE, Hanssen E, Marapana DS, Fernandez IS, Ralph SA, Cowman AF, Scheres SHW, Baum J. Nat Microbiol 2 17031 (2017)
  21. Microbial biotransformation of DON: molecular basis for reduced toxicity. Pierron A, Mimoun S, Murate LS, Loiseau N, Lippi Y, Bracarense AP, Schatzmayr G, He JW, Zhou T, Moll WD, Oswald IP. Sci Rep 6 29105 (2016)
  22. Genome-wide Survey of Ribosome Collision. Han P, Shichino Y, Schneider-Poetsch T, Mito M, Hashimoto S, Udagawa T, Kohno K, Yoshida M, Mishima Y, Inada T, Iwasaki S. Cell Rep 31 107610 (2020)
  23. UFMylation of RPL26 links translocation-associated quality control to endoplasmic reticulum protein homeostasis. Wang L, Xu Y, Rogers H, Saidi L, Noguchi CT, Li H, Yewdell JW, Guydosh NR, Ye Y. Cell Res 30 5-20 (2020)
  24. The complete chemical structure of Saccharomyces cerevisiae rRNA: partial pseudouridylation of U2345 in 25S rRNA by snoRNA snR9. Taoka M, Nobe Y, Yamaki Y, Yamauchi Y, Ishikawa H, Takahashi N, Nakayama H, Isobe T. Nucleic Acids Res 44 8951-8961 (2016)
  25. Visualization of cytosolic ribosomes on the surface of mitochondria by electron cryo-tomography. Gold VA, Chroscicki P, Bragoszewski P, Chacinska A. EMBO Rep 18 1786-1800 (2017)
  26. Novel small molecules potentiate premature termination codon readthrough by aminoglycosides. Baradaran-Heravi A, Balgi AD, Zimmerman C, Choi K, Shidmoossavee FS, Tan JS, Bergeaud C, Krause A, Flibotte S, Shimizu Y, Anderson HJ, Mouly V, Jan E, Pfeifer T, Jaquith JB, Roberge M. Nucleic Acids Res 44 6583-6598 (2016)
  27. Characterization of new-generation aminoglycoside promoting premature termination codon readthrough in cancer cells. Bidou L, Bugaud O, Belakhov V, Baasov T, Namy O. RNA Biol 14 378-388 (2017)
  28. Decoding the Function of Expansion Segments in Ribosomes. Fujii K, Susanto TT, Saurabh S, Barna M. Mol Cell 72 1013-1020.e6 (2018)
  29. Functional Dynamics within the Human Ribosome Regulate the Rate of Active Protein Synthesis. Ferguson A, Wang L, Altman RB, Terry DS, Juette MF, Burnett BJ, Alejo JL, Dass RA, Parks MM, Vincent CT, Blanchard SC. Mol Cell 60 475-486 (2015)
  30. Co-translational assembly of mammalian nuclear multisubunit complexes. Kamenova I, Mukherjee P, Conic S, Mueller F, El-Saafin F, Bardot P, Garnier JM, Dembele D, Capponi S, Timmers HTM, Vincent SD, Tora L. Nat Commun 10 1740 (2019)
  31. A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism. Eyal Z, Matzov D, Krupkin M, Paukner S, Riedl R, Rozenberg H, Zimmerman E, Bashan A, Yonath A. Sci Rep 6 39004 (2016)
  32. Nascent Polypeptide Domain Topology and Elongation Rate Direct the Cotranslational Hierarchy of Hsp70 and TRiC/CCT. Stein KC, Kriel A, Frydman J. Mol Cell 75 1117-1130.e5 (2019)
  33. Structure-function insights reveal the human ribosome as a cancer target for antibiotics. Myasnikov AG, Kundhavai Natchiar S, Nebout M, Hazemann I, Imbert V, Khatter H, Peyron JF, Klaholz BP. Nat Commun 7 12856 (2016)
  34. Zinc starvation induces autophagy in yeast. Kawamata T, Horie T, Matsunami M, Sasaki M, Ohsumi Y. J Biol Chem 292 8520-8530 (2017)
  35. Ribosome queuing enables non-AUG translation to be resistant to multiple protein synthesis inhibitors. Kearse MG, Goldman DH, Choi J, Nwaezeapu C, Liang D, Green KM, Goldstrohm AC, Todd PK, Green R, Wilusz JE. Genes Dev 33 871-885 (2019)
  36. Gentamicin B1 is a minor gentamicin component with major nonsense mutation suppression activity. Baradaran-Heravi A, Niesser J, Balgi AD, Choi K, Zimmerman C, South AP, Anderson HJ, Strynadka NC, Bally MB, Roberge M. Proc Natl Acad Sci U S A 114 3479-3484 (2017)
  37. Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes. Zhang X, Lai M, Chang W, Yu I, Ding K, Mrazek J, Ng HL, Yang OO, Maslov DA, Zhou ZH. Nat Commun 7 13223 (2016)
  38. Deoxynivalenol and its metabolite deepoxy-deoxynivalenol: multi-parameter analysis for the evaluation of cytotoxicity and cellular effects. Springler A, Hessenberger S, Reisinger N, Kern C, Nagl V, Schatzmayr G, Mayer E. Mycotoxin Res 33 25-37 (2017)
  39. Multi-omics analysis reveals regulators of the response to nitrogen limitation in Yarrowia lipolytica. Pomraning KR, Kim YM, Nicora CD, Chu RK, Bredeweg EL, Purvine SO, Hu D, Metz TO, Baker SE. BMC Genomics 17 138 (2016)
  40. Puromycin reactivity does not accurately localize translation at the subcellular level. Enam SU, Zinshteyn B, Goldman DH, Cassani M, Livingston NM, Seydoux G, Green R. Elife 9 e60303 (2020)
  41. Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule. Li W, Ward FR, McClure KF, Chang ST, Montabana E, Liras S, Dullea RG, Cate JHD. Nat Struct Mol Biol 26 501-509 (2019)
  42. Effects of cycloheximide on the interpretation of ribosome profiling experiments in Schizosaccharomyces pombe. Duncan CDS, Mata J. Sci Rep 7 10331 (2017)
  43. 4EHP and GIGYF1/2 Mediate Translation-Coupled Messenger RNA Decay. Weber R, Chung MY, Keskeny C, Zinnall U, Landthaler M, Valkov E, Izaurralde E, Igreja C. Cell Rep 33 108262 (2020)
  44. Four translation initiation pathways employed by the leaderless mRNA in eukaryotes. Akulich KA, Andreev DE, Terenin IM, Smirnova VV, Anisimova AS, Makeeva DS, Arkhipova VI, Stolboushkina EA, Garber MB, Prokofjeva MM, Spirin PV, Prassolov VS, Shatsky IN, Dmitriev SE. Sci Rep 6 37905 (2016)
  45. 'Z-DNA like' fragments in RNA: a recurring structural motif with implications for folding, RNA/protein recognition and immune response. D'Ascenzo L, Leonarski F, Vicens Q, Auffinger P. Nucleic Acids Res 44 5944-5956 (2016)
  46. The IRES5'UTR of the dicistrovirus cricket paralysis virus is a type III IRES containing an essential pseudoknot structure. Gross L, Vicens Q, Einhorn E, Noireterre A, Schaeffer L, Kuhn L, Imler JL, Eriani G, Meignin C, Martin F. Nucleic Acids Res 45 8993-9004 (2017)
  47. The enzymatic epimerization of deoxynivalenol by Devosia mutans proceeds through the formation of 3-keto-DON intermediate. Hassan YI, He JW, Perilla N, Tang K, Karlovsky P, Zhou T. Sci Rep 7 6929 (2017)
  48. A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors. Ren PX, Shang WJ, Yin WC, Ge H, Wang L, Zhang XL, Li BQ, Li HL, Xu YC, Xu EH, Jiang HL, Zhu LL, Zhang LK, Bai F. Acta Pharmacol Sin 43 483-493 (2022)
  49. Ataluren and aminoglycosides stimulate read-through of nonsense codons by orthogonal mechanisms. Ng MY, Li H, Ghelfi MD, Goldman YE, Cooperman BS. Proc Natl Acad Sci U S A 118 e2020599118 (2021)
  50. Narrow Leaf21, encoding ribosomal protein RPS3A, controls leaf development in rice. Uzair M, Long H, Zafar SA, Patil SB, Chun Y, Li L, Fang J, Zhao J, Peng L, Yuan S, Li X. Plant Physiol 186 497-518 (2021)
  51. Preribosomes escaping from the nucleus are caught during translation by cytoplasmic quality control. Sarkar A, Thoms M, Barrio-Garcia C, Thomson E, Flemming D, Beckmann R, Hurt E. Nat Struct Mol Biol 24 1107-1115 (2017)
  52. Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM. Loveland AB, Svidritskiy E, Susorov D, Lee S, Park A, Zvornicanin S, Demo G, Gao FB, Korostelev AA. Nat Commun 13 2776 (2022)
  53. Proteome-wide mapping of short-lived proteins in human cells. Li J, Cai Z, Vaites LP, Shen N, Mitchell DC, Huttlin EL, Paulo JA, Harry BL, Gygi SP. Mol Cell 81 4722-4735.e5 (2021)
  54. Transcriptome-wide measurement of ribosomal occupancy by ribosome profiling. Aeschimann F, Xiong J, Arnold A, Dieterich C, Großhans H. Methods 85 75-89 (2015)
  55. A harmine-derived beta-carboline displays anti-cancer effects in vitro by targeting protein synthesis. Carvalho A, Chu J, Meinguet C, Kiss R, Vandenbussche G, Masereel B, Wouters J, Kornienko A, Pelletier J, Mathieu V. Eur J Pharmacol 805 25-35 (2017)
  56. Design of Novel Aminoglycoside Derivatives with Enhanced Suppression of Diseases-Causing Nonsense Mutations. Sabbavarapu NM, Shavit M, Degani Y, Smolkin B, Belakhov V, Baasov T. ACS Med Chem Lett 7 418-423 (2016)
  57. Determinants of genome-wide distribution and evolution of uORFs in eukaryotes. Zhang H, Wang Y, Wu X, Tang X, Wu C, Lu J. Nat Commun 12 1076 (2021)
  58. Structural basis for selective targeting of leishmanial ribosomes: aminoglycoside derivatives as promising therapeutics. Shalev M, Rozenberg H, Smolkin B, Nasereddin A, Kopelyanskiy D, Belakhov V, Schrepfer T, Schacht J, Jaffe CL, Adir N, Baasov T. Nucleic Acids Res 43 8601-8613 (2015)
  59. SunRiSE - measuring translation elongation at single-cell resolution by means of flow cytometry. Argüello RJ, Reverendo M, Mendes A, Camosseto V, Torres AG, Ribas de Pouplana L, van de Pavert SA, Gatti E, Pierre P. J Cell Sci 131 jcs214346 (2018)
  60. Tetracyclines Modify Translation by Targeting Key Human rRNA Substructures. Mortison JD, Schenone M, Myers JA, Zhang Z, Chen L, Ciarlo C, Comer E, Natchiar SK, Carr SA, Klaholz BP, Myers AG. Cell Chem Biol 25 1506-1518.e13 (2018)
  61. The minor gentamicin complex component, X2, is a potent premature stop codon readthrough molecule with therapeutic potential. Friesen WJ, Johnson B, Sierra J, Zhuo J, Vazirani P, Xue X, Tomizawa Y, Baiazitov R, Morrill C, Ren H, Babu S, Moon YC, Branstrom A, Mollin A, Hedrick J, Sheedy J, Elfring G, Weetall M, Colacino JM, Welch EM, Peltz SW. PLoS One 13 e0206158 (2018)
  62. Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome. Prokhorova IV, Akulich KA, Makeeva DS, Osterman IA, Skvortsov DA, Sergiev PV, Dontsova OA, Yusupova G, Yusupov MM, Dmitriev SE. Sci Rep 6 27720 (2016)
  63. Appropriateness to set a group health based guidance value for T2 and HT2 toxin and its modified forms. EFSA Panel on Contaminants in the Food Chain (CONTAM), Knutsen HK, Barregård L, Bignami M, Brüschweiler B, Ceccatelli S, Cottrill B, Dinovi M, Edler L, Grasl-Kraupp B, Hogstrand C, Hoogenboom LR, Nebbia CS, Oswald I, Petersen A, Rose M, Roudot AC, Schwerdtle T, Vleminckx C, Vollmer G, Wallace H, Dall'Asta C, Gutleb A, Metzler M, Oswald I, Parent-Massin D, Binaglia M, Steinkellner H, Alexander J. EFSA J 15 e04655 (2017)
  64. Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine. Arango D, Sturgill D, Yang R, Kanai T, Bauer P, Roy J, Wang Z, Hosogane M, Schiffers S, Oberdoerffer S. Mol Cell 82 2797-2814.e11 (2022)
  65. Global shape mimicry of tRNA within a viral internal ribosome entry site mediates translational reading frame selection. Au HH, Cornilescu G, Mouzakis KD, Ren Q, Burke JE, Lee S, Butcher SE, Jan E. Proc Natl Acad Sci U S A 112 E6446-55 (2015)
  66. New in Vitro Assay Measuring Direct Interaction of Nonsense Suppressors with the Eukaryotic Protein Synthesis Machinery. Ng MY, Zhang H, Weil A, Singh V, Jamiolkowski R, Baradaran-Heravi A, Roberge M, Jacobson A, Friesen W, Welch E, Goldman YE, Cooperman BS. ACS Med Chem Lett 9 1285-1291 (2018)
  67. Structural analysis of 70S ribosomes by cross-linking/mass spectrometry reveals conformational plasticity. Tüting C, Iacobucci C, Ihling CH, Kastritis PL, Sinz A. Sci Rep 10 12618 (2020)
  68. USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit. Montellese C, van den Heuvel J, Ashiono C, Dörner K, Melnik A, Jonas S, Zemp I, Picotti P, Gillet LC, Kutay U. Elife 9 e54435 (2020)
  69. Homoharringtonine induced immune alteration for an Efficient Anti-tumor Response in Mouse Models of Non-small Cell Lung Adenocarcinoma Expressing Kras Mutation. Weng TY, Wu HF, Li CY, Hung YH, Chang YW, Chen YL, Hsu HP, Chen YH, Wang CY, Chang JY, Lai MD. Sci Rep 8 8216 (2018)
  70. Lycorine inhibits glioblastoma multiforme growth through EGFR suppression. Shen J, Zhang T, Cheng Z, Zhu N, Wang H, Lin L, Wang Z, Yi H, Hu M. J Exp Clin Cancer Res 37 157 (2018)
  71. Eukaryotic translation elongation factor 2 (eEF2) catalyzes reverse translocation of the eukaryotic ribosome. Susorov D, Zakharov N, Shuvalova E, Ivanov A, Egorova T, Shuvalov A, Shatsky IN, Alkalaeva E. J Biol Chem 293 5220-5229 (2018)
  72. In silico analysis sheds light on the structural basis underlying the ribotoxicity of trichothecenes-A tool for supporting the hazard identification process. Dellafiora L, Galaverna G, Dall'Asta C. Toxicol Lett 270 80-87 (2017)
  73. Multiple folding pathways of proteins with shallow knots and co-translational folding. Chwastyk M, Cieplak M. J Chem Phys 143 045101 (2015)
  74. Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii. Li Z, Guo Q, Zheng L, Ji Y, Xie YT, Lai DH, Lun ZR, Suo X, Gao N. Cell Res 27 1275-1288 (2017)
  75. Effects of the 1- N-(4-Amino-2 S-hydroxybutyryl) and 6'- N-(2-Hydroxyethyl) Substituents on Ribosomal Selectivity, Cochleotoxicity, and Antibacterial Activity in the Sisomicin Class of Aminoglycoside Antibiotics. Sonousi A, Sarpe VA, Brilkova M, Schacht J, Vasella A, Böttger EC, Crich D. ACS Infect Dis 4 1114-1120 (2018)
  76. Enantioselective Synthesis of Isocarbostyril Alkaloids and Analogs Using Catalytic Dearomative Functionalization of Benzene. Bingham TW, Hernandez LW, Olson DG, Svec RL, Hergenrother PJ, Sarlah D. J Am Chem Soc 141 657-670 (2019)
  77. Purification of mRNA-programmed translation initiation complexes suitable for mass spectrometry analysis. Chicher J, Simonetti A, Kuhn L, Schaeffer L, Hammann P, Eriani G, Martin F. Proteomics 15 2417-2425 (2015)
  78. Ribosomal RNA 2'-O-methylations regulate translation by impacting ribosome dynamics. Khoshnevis S, Dreggors-Walker RE, Marchand V, Motorin Y, Ghalei H. Proc Natl Acad Sci U S A 119 e2117334119 (2022)
  79. The eukaryote-specific N-terminal extension of ribosomal protein S31 contributes to the assembly and function of 40S ribosomal subunits. Fernández-Pevida A, Martín-Villanueva S, Murat G, Lacombe T, Kressler D, de la Cruz J. Nucleic Acids Res 44 7777-7791 (2016)
  80. Blasticidin-S deaminase, a new selection marker for genetic transformation of the diatom Phaeodactylum tricornutum. Buck JM, Río Bártulos C, Gruber A, Kroth PG. PeerJ 6 e5884 (2018)
  81. Crystal Structures of the uL3 Mutant Ribosome: Illustration of the Importance of Ribosomal Proteins for Translation Efficiency. Mailliot J, Garreau de Loubresse N, Yusupova G, Meskauskas A, Dinman JD, Yusupov M. J Mol Biol 428 2195-2202 (2016)
  82. Genome editing enables reverse genetics of multicellular development in the choanoflagellate Salpingoeca rosetta. Booth DS, King N. Elife 9 e56193 (2020)
  83. Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides. Könst ZA, Szklarski AR, Pellegrino S, Michalak SE, Meyer M, Zanette C, Cencic R, Nam S, Voora VK, Horne DA, Pelletier J, Mobley DL, Yusupova G, Yusupov M, Vanderwal CD. Nat Chem 9 1140-1149 (2017)
  84. The antimalarial drug mefloquine enhances TP53 premature termination codon readthrough by aminoglycoside G418. Ferguson MW, Gerak CAN, Chow CCT, Rastelli EJ, Elmore KE, Stahl F, Hosseini-Farahabadi S, Baradaran-Heravi A, Coltart DM, Roberge M. PLoS One 14 e0216423 (2019)
  85. Cellular response to small molecules that selectively stall protein synthesis by the ribosome. Liaud N, Horlbeck MA, Gilbert LA, Gjoni K, Weissman JS, Cate JHD. PLoS Genet 15 e1008057 (2019)
  86. Beyond Ribosomal Binding: The Increased Polarity and Aberrant Molecular Interactions of 3-epi-deoxynivalenol. Hassan YI, Zhu H, Zhu Y, Zhou T. Toxins (Basel) 8 E261 (2016)
  87. The Fusarium metabolite culmorin suppresses the in vitro glucuronidation of deoxynivalenol. Woelflingseder L, Warth B, Vierheilig I, Schwartz-Zimmermann H, Hametner C, Nagl V, Novak B, Šarkanj B, Berthiller F, Adam G, Marko D. Arch Toxicol 93 1729-1743 (2019)
  88. The Ribosome-Binding Mode of Trichothecene Mycotoxins Rationalizes Their Structure-Activity Relationships. Wang W, Zhu Y, Abraham N, Li XZ, Kimber M, Zhou T. Int J Mol Sci 22 1604 (2021)
  89. Adaptation to genome decay in the structure of the smallest eukaryotic ribosome. Nicholson D, Salamina M, Panek J, Helena-Bueno K, Brown CR, Hirt RP, Ranson NA, Melnikov SV. Nat Commun 13 591 (2022)
  90. Exploring the Effect of Polypyridyl Ligands on the Anticancer Activity of Phosphorescent Iridium(III) Complexes: From Proteosynthesis Inhibitors to Photodynamic Therapy Agents. Pracharova J, Vigueras G, Novohradsky V, Cutillas N, Janiak C, Kostrhunova H, Kasparkova J, Ruiz J, Brabec V. Chemistry 24 4607-4619 (2018)
  91. Functional analysis of the uL11 protein impact on translational machinery. Wawiórka L, Molestak E, Szajwaj M, Michalec-Wawiórka B, Boguszewska A, Borkiewicz L, Liudkovska V, Kufel J, Tchórzewski M. Cell Cycle 15 1060-1072 (2016)
  92. Genomics-Driven Discovery of a Novel Glutarimide Antibiotic from Burkholderia gladioli Reveals an Unusual Polyketide Synthase Chain Release Mechanism. Nakou IT, Jenner M, Dashti Y, Romero-Canelón I, Masschelein J, Mahenthiralingam E, Challis GL. Angew Chem Int Ed Engl 59 23145-23153 (2020)
  93. Mechanism of Inhibition of Translation Termination by Blasticidin S. Svidritskiy E, Korostelev AA. J Mol Biol 430 591-593 (2018)
  94. Risk to human and animal health related to the presence of 4,15-diacetoxyscirpenol in food and feed. EFSA Panel on Contaminants in the Food Chain (CONTAM), Knutsen HK, Alexander J, Barregård L, Bignami M, Brüschweiler B, Ceccatelli S, Cottrill B, Dinovi M, Grasl-Kraupp B, Hogstrand C, Hoogenboom LR, Nebbia CS, Oswald IP, Petersen A, Rose M, Roudot AC, Schwerdtle T, Vleminckx C, Vollmer G, Wallace H, De Saeger S, Eriksen GS, Farmer P, Fremy JM, Gong YY, Gong YY, Meyer K, Parent-Massin D, van Egmond H, Altieri A, Colombo P, Horváth Z, Levorato S, Edler L. EFSA J 16 e05367 (2018)
  95. The Functional Role of eL19 and eB12 Intersubunit Bridge in the Eukaryotic Ribosome. Kisly I, Gulay SP, Mäeorg U, Dinman JD, Remme J, Tamm T. J Mol Biol 428 2203-2216 (2016)
  96. A unified dinucleotide alphabet describing both RNA and DNA structures. Černý J, Božíková P, Svoboda J, Schneider B. Nucleic Acids Res 48 6367-6381 (2020)
  97. Humans and other commonly used model organisms are resistant to cycloheximide-mediated biases in ribosome profiling experiments. Sharma P, Wu J, Nilges BS, Leidel SA. Nat Commun 12 5094 (2021)
  98. The Plasmodium falciparum cytoplasmic translation apparatus: a promising therapeutic target not yet exploited by clinically approved anti-malarials. Sheridan CM, Garcia VE, Ahyong V, DeRisi JL. Malar J 17 465 (2018)
  99. Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome. Pellegrino S, Meyer M, Könst ZA, Holm M, Voora VK, Kashinskaya D, Zanette C, Mobley DL, Yusupova G, Vanderwal CD, Blanchard SC, Yusupov M. Nucleic Acids Res 47 3223-3232 (2019)
  100. Yeast translation elongation factor eEF3 promotes late stages of tRNA translocation. Ranjan N, Pochopien AA, Chih-Chien Wu C, Beckert B, Blanchet S, Green R, V Rodnina M, Wilson DN. EMBO J 40 e106449 (2021)
  101. 2-Aminothiazole-4-carboxamides Enhance Readthrough of Premature Termination Codons by Aminoglycosides. Rabea SM, Baradaran-Heravi A, Balgi AD, Krause A, Hosseini Farahabadi S, Roberge M, Grierson DS. ACS Med Chem Lett 10 726-731 (2019)
  102. Expansion of germline RPS20 mutation phenotype to include Diamond-Blackfan anemia. Bhar S, Zhou F, Reineke LC, Morris DK, Khincha PP, Giri N, Mirabello L, Bergstrom K, Lemon LD, Williams CL, Toh Y, Elghetany MT, Lloyd RE, Alter BP, Savage SA, Bertuch AA. Hum Mutat 41 1918-1930 (2020)
  103. Genomic and Secondary Metabolite Analyses of Streptomyces sp. 2AW Provide Insight into the Evolution of the Cycloheximide Pathway. Stulberg ER, Lozano GL, Morin JB, Park H, Baraban EG, Mlot C, Heffelfinger C, Phillips GM, Rush JS, Phillips AJ, Broderick NA, Thomas MG, Stabb EV, Handelsman J. Front Microbiol 7 573 (2016)
  104. Nonselective TRPC channel inhibition and suppression of aminoglycoside-induced premature termination codon readthrough by the small molecule AC1903. Baradaran-Heravi A, Bauer CC, Pickles IB, Hosseini-Farahabadi S, Balgi AD, Choi K, Linley DM, Beech DJ, Roberge M, Bon RS. J Biol Chem 298 101546 (2022)
  105. One-shot analysis of translated mammalian lncRNAs with AHARIBO. Minati L, Firrito C, Del Piano A, Peretti A, Sidoli S, Peroni D, Belli R, Gandolfi F, Romanel A, Bernabo P, Zasso J, Quattrone A, Guella G, Lauria F, Viero G, Clamer M. Elife 10 e59303 (2021)
  106. Stabilization of eukaryotic ribosomal termination complexes by deacylated tRNA. Susorov D, Mikhailova T, Ivanov A, Sokolova E, Alkalaeva E. Nucleic Acids Res 43 3332-3343 (2015)
  107. Translation Inhibitors Activate Autophagy Master Regulators TFEB and TFE3. Dang TT, Back SH. Int J Mol Sci 22 12083 (2021)
  108. Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA. Powers KT, Stevenson-Jones F, Yadav SKN, Amthor B, Bufton JC, Borucu U, Shen D, Becker JP, Lavysh D, Hentze MW, Kulozik AE, Neu-Yilik G, Schaffitzel C. Nucleic Acids Res 49 7665-7679 (2021)
  109. Deoxynivalenol Affects Proliferation and Expression of Activation-Related Molecules in Major Porcine T-Cell Subsets. Vatzia E, Pierron A, Saalmüller A, Mayer E, Gerner W. Toxins (Basel) 11 E644 (2019)
  110. Ribosome quality control is a central protection mechanism for yeast exposed to deoxynivalenol and trichothecin. Kugler KG, Jandric Z, Beyer R, Klopf E, Glaser W, Lemmens M, Shams M, Mayer K, Adam G, Schüller C. BMC Genomics 17 417 (2016)
  111. iTRAQ-based quantitative proteomic analysis reveals dynamic changes during daylily flower senescence. Ma G, Shi X, Zou Q, Tian D, An X, Zhu K. Planta 248 859-873 (2018)
  112. Biodegradation of Deoxynivalenol by Nocardioides sp. ZHH-013: 3-keto-Deoxynivalenol and 3-epi-Deoxynivalenol as Intermediate Products. Zhang H, Zhang H, Qin X, Wang X, Wang Y, Bin Y, Xie X, Zheng F, Luo H. Front Microbiol 12 658421 (2021)
  113. Didemnin B and ternatin-4 differentially inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes. Juette MF, Carelli JD, Rundlet EJ, Brown A, Shao S, Ferguson A, Wasserman MR, Holm M, Taunton J, Blanchard SC. Elife 11 e81608 (2022)
  114. Eukaryotic Translation Initiation Factor 4AI: A Potential Novel Target in Neuroblastoma. Skofler C, Kleinegger F, Krassnig S, Birkl-Toeglhofer AM, Singer G, Till H, Benesch M, Cencic R, Porco JA, Pelletier J, Castellani C, Raicht A, Izycka-Swieszewska E, Czapiewski P, Haybaeck J. Cells 10 301 (2021)
  115. Ratchet, swivel, tilt and roll: a complete description of subunit rotation in the ribosome. Hassan A, Byju S, Freitas FC, Roc C, Pender N, Nguyen K, Kimbrough EM, Mattingly JM, Gonzalez RL, de Oliveira RJ, Dunham CM, Whitford PC. Nucleic Acids Res 51 919-934 (2023)
  116. Structure of the translating Neurospora ribosome arrested by cycloheximide. Shen L, Su Z, Yang K, Wu C, Becker T, Bell-Pedersen D, Zhang J, Sachs MS. Proc Natl Acad Sci U S A 118 e2111862118 (2021)
  117. mRNA regions where 80S ribosomes pause during translation elongation in vivo interact with protein uS19, a component of the decoding site. Babaylova ES, Gopanenko AV, Bulygin KN, Tupikin AE, Kabilov MR, Malygin AA, Karpova GG. Nucleic Acids Res 48 912-923 (2020)
  118. A Bivalent Securinine Compound SN3-L6 Induces Neuronal Differentiation via Translational Upregulation of Neurogenic Transcription Factors. Liao Y, Zhuang X, Huang X, Peng Y, Ma X, Huang ZX, Liu F, Xu J, Wang Y, Chen WM, Ye WC, Shi L. Front Pharmacol 9 290 (2018)
  119. Amino acid deprivation triggers a novel GCN2-independent response leading to the transcriptional reactivation of non-native DNA sequences. De Vito A, Lazzaro M, Palmisano I, Cittaro D, Riba M, Lazarevic D, Lazarevic D, Bannai M, Gabellini D, Schiaffino MV. PLoS One 13 e0200783 (2018)
  120. Exploring the dermotoxicity of the mycotoxin deoxynivalenol: combined morphologic and proteomic profiling of human epidermal cells reveals alteration of lipid biosynthesis machinery and membrane structural integrity relevant for skin barrier function. Del Favero G, Janker L, Neuditschko B, Hohenbichler J, Kiss E, Woelflingseder L, Gerner C, Marko D. Arch Toxicol 95 2201-2221 (2021)
  121. Mapping platinum adducts on yeast ribosomal RNA using high-throughput sequencing. Plakos K, DeRose VJ. Chem Commun (Camb) 53 12746-12749 (2017)
  122. Pro-Inflammatory Effects of NX-3 Toxin Are Comparable to Deoxynivalenol and not Modulated by the Co-Occurring Pro-Oxidant Aurofusarin. Woelflingseder L, Gruber N, Adam G, Marko D. Microorganisms 8 E603 (2020)
  123. A proposal for clinical trials of COVID-19 treatment using homo-harringtonine. Wen HJ, Liu FL, Huang MX, Luo RH, He WB, Feng J, Chen FL, Cai QC, Ma HJ, Yang ZF, Zhou X, Shang Y, Lyu XM, Zhang DY, Xiao F, Shan H, He JX, Zheng YT, Wu CI. Natl Sci Rev 8 nwaa257 (2021)
  124. Deciphering the protein translation inhibition and coping mechanism of trichothecene toxin in resistant fungi. Kumari I, Ahmed M, Akhter Y. Int J Biochem Cell Biol 78 370-376 (2016)
  125. Deoxynivalenol reduces quality parameters and increases DNA damage in mice spermatozoa. Hallaj Salahipour M, Hasanzadeh S, Malekinejad H, Razi M, Farrokhi-Ardebili F. Andrologia 51 e13238 (2019)
  126. Development and characterization of anti-fibrotic natural compound similars with improved effectivity. Kreutzer FP, Meinecke A, Mitzka S, Hunkler HJ, Hobuß L, Abbas N, Geffers R, Weusthoff J, Xiao K, Jonigk DD, Fiedler J, Thum T. Basic Res Cardiol 117 9 (2022)
  127. Eukaryotic Ribosome as a Target for Cardiovascular Disease. Pellegrino S, Yusupova G. Cell Chem Biol 23 1319-1321 (2016)
  128. Exploring eukaryotic versus prokaryotic ribosomal RNA recognition with aminoglycoside derivatives. Sabbavarapu NM, Pieńko T, Zalman BH, Trylska J, Baasov T. Medchemcomm 9 503-508 (2018)
  129. Global translation inhibition yields condition-dependent de-repression of ribosome biogenesis mRNAs. Cheng Z, Brar GA. Nucleic Acids Res 47 5061-5073 (2019)
  130. Identifying the Cellular Target of Cordyheptapeptide A and Synthetic Derivatives. Klein VG, Bray WM, Wang HY, Edmondson Q, Schwochert J, Ono S, Naylor MR, Turmon AC, Faris JH, Okada O, Taunton J, Lokey RS. ACS Chem Biol 16 1354-1364 (2021)
  131. Reducing the Toxicity of Designer Aminoglycosides as Nonsense Mutation Readthrough Agents for Therapeutic Targets. Popadynec M, Baradaran-Heravi A, Alford B, Cameron SA, Clinch K, Mason JM, Rendle PM, Zubkova OV, Gan Z, Liu H, Rebollo O, Whitfield DM, Yan F, Roberge M, Powell DA. ACS Med Chem Lett 12 1486-1492 (2021)
  132. Synthesis and Biological Evaluation of Lactimidomycin and Its Analogues. Larsen BJ, Sun Z, Lachacz E, Khomutnyk Y, Soellner MB, Nagorny P. Chemistry 21 19159-19167 (2015)
  133. tRNA-derived fragments from wheat are potentially involved in susceptibility to Fusarium head blight. Sun Z, Hu Y, Zhou Y, Jiang N, Hu S, Li L, Li T. BMC Plant Biol 22 3 (2022)
  134. Analysis of subunit folding contribution of three yeast large ribosomal subunit proteins required for stabilisation and processing of intermediate nuclear rRNA precursors. Pöll G, Pilsl M, Griesenbeck J, Tschochner H, Milkereit P. PLoS One 16 e0252497 (2021)
  135. CRISPR-SCReT (CRISPR-Stop Codon Read Through) method to control Cas9 expression for gene editing. Yaméogo P, Duchêne BL, Majeau N, Tremblay JP. Gene Ther 29 171-177 (2022)
  136. CryoEM structures of pseudouridine-free ribosome suggest impacts of chemical modifications on ribosome conformations. Zhao Y, Rai J, Yu H, Li H. Structure 30 983-992.e5 (2022)
  137. Deoxynivalenol Has the Capacity to Increase Transcription Factor Expression and Cytokine Production in Porcine T Cells. Vatzia E, Pierron A, Hoog AM, Saalmüller A, Mayer E, Gerner W. Front Immunol 11 2009 (2020)
  138. Diverse targets of SMN2-directed splicing-modulating small molecule therapeutics for spinal muscular atrophy. Ottesen EW, Singh NN, Luo D, Kaas B, Gillette BJ, Seo J, Jorgensen HJ, Singh RN. Nucleic Acids Res 51 5948-5980 (2023)
  139. E-site drug specificity of the human pathogen Candida albicans ribosome. Zgadzay Y, Kolosova O, Stetsenko A, Wu C, Bruchlen D, Usachev K, Validov S, Jenner L, Rogachev A, Yusupova G, Sachs MS, Guskov A, Yusupov M. Sci Adv 8 eabn1062 (2022)
  140. Geneticin shows selective antiviral activity against SARS-CoV-2 by interfering with programmed -1 ribosomal frameshifting. Varricchio C, Mathez G, Pillonel T, Bertelli C, Kaiser L, Tapparel C, Brancale A, Cagno V. Antiviral Res 208 105452 (2022)
  141. Heightened protein-translation activities in mammalian cells and the disease/treatment implications. Wu CI, Wen H. Natl Sci Rev 7 1851-1855 (2020)
  142. Letter Homo-harringtonine, highly effective against coronaviruses, is safe in treating COVID-19 by nebulization. Ma H, Wen H, Qin Y, Wu S, Zhang G, Wu CI, Cai Q. Sci China Life Sci 65 1263-1266 (2022)
  143. Translation inhibitory elements from Hoxa3 and Hoxa11 mRNAs use uORFs for translation inhibition. Alghoul F, Laure S, Eriani G, Martin F. Elife 10 e66369 (2021)
  144. mRNA decoding in human is kinetically and structurally distinct from bacteria. Holm M, Natchiar SK, Rundlet EJ, Myasnikov AG, Watson ZL, Altman RB, Wang HY, Taunton J, Blanchard SC. Nature 617 200-207 (2023)
  145. A broad-spectrum antiviral molecule, QL47, selectively inhibits eukaryotic translation. de Wispelaere M, Carocci M, Burri DJ, Neidermyer WJ, Olson CM, Roggenbach I, Liang Y, Wang J, Whelan SPJ, Gray NS, Yang PL. J Biol Chem 295 1694-1703 (2020)
  146. Discovery of C13-Aminobenzoyl Cycloheximide Derivatives that Potently Inhibit Translation Elongation. Koga Y, Hoang EM, Park Y, Keszei AFA, Murray J, Shao S, Liau BB. J Am Chem Soc 143 13473-13477 (2021)
  147. Selectivity of commercial immunoaffinity columns for modified forms of the mycotoxin 4-deoxynivalenol (DON). Uhlig S, Stanic A, Hussain F, Miles CO. J Chromatogr B Analyt Technol Biomed Life Sci 1061-1062 322-326 (2017)
  148. Site saturation mutagenesis of ribosomal protein L42 at 56th residue and application as a consecutive selection marker for cycloheximide resistance in yeast. Bae JH, Sung BH, Sohn JH. FEMS Microbiol Lett 365 (2018)
  149. Solvent and Water Mediated Structural Variations in Deoxynivalenol and Their Potential Implications on the Disruption of Ribosomal Function. Foroud NA, Shank RA, Kiss D, Eudes F, Hazendonk P. Front Microbiol 7 1239 (2016)
  150. Structure-Based Design of a Eukaryote-Selective Antiprotozoal Fluorinated Aminoglycoside. Kanazawa H, Saavedra OM, Maianti JP, Young SA, Izquierdo L, Smith TK, Hanessian S, Kondo J. ChemMedChem 13 1541-1548 (2018)
  151. Synthesis and biological evaluation of 10-benzyloxy-Narciclasine. Ticli V, Zhao Z, Du L, Kornienko A, Hudlicky T. Tetrahedron 101 132505 (2021)
  152. Two Different Inoculation Methods Unveiled the Relative Independence of DON Accumulation in Wheat Kernels from Disease Severity on Spike after Infection by Fusarium Head Blight. Wang R, Hua C, Hu Y, Li L, Sun Z, Li T. Toxins (Basel) 13 353 (2021)
  153. A Functional Role for the Monomethylated Gln-51 and Lys-53 Residues of the 49GGQTK53 Motif of eL42 from Human 80S Ribosomes. Eustache S, Créchet JB, Bouceba T, Nakayama JI, Tanaka M, Suzuki M, Woisard A, Tuffery P, Baouz S, Hountondji C. Open Biochem J 11 8-26 (2017)
  154. A Novel Deoxynivalenol-Activated Wheat Arl6ip4 Gene Encodes an Antifungal Peptide with Deoxynivalenol Affinity and Protects Plants against Fusarium Pathogens and Mycotoxins. Liu G, Zuo DY, Yang P, He WJ, Yang Z, Zhang JB, Wu AB, Yi SY, Li HP, Huang T, Liao YC. J Fungi (Basel) 7 941 (2021)
  155. A concise formal total synthesis of lactimidomycin. Li W, Georg GI. Chem Commun (Camb) 51 8634-8636 (2015)
  156. Amaryllidaceae Alkaloids Decrease the Proliferation, Invasion, and Secretion of Clinically Relevant Cytokines by Cultured Human Colon Cancer Cells. Mathieu V, Laguera B, Masi M, Dulanto SA, Bingham TW, Hernandez LW, Sarlah D, Evidente A, Lafontaine DLJ, Kornienko A, Lane MA. Biomolecules 12 1267 (2022)
  157. Editorial Antimicrobial peptides targeting bacterial ribosome. Lomakin IB, Gagnon MG, Steitz TA. Oncotarget 6 18744-18745 (2015)
  158. Cis-regulatory elements and transcription factors related to auxin signaling in the streptophyte algae Klebsormidium nitens. Tounosu N, Sesoko K, Hori K, Shimojima M, Ohta H. Sci Rep 13 9635 (2023)
  159. Engineering and functional analysis of yeast with a monotypic 40S ribosome subunit. Hu X, Jiang S, Xu F, Zeng C, Wang X, Liu W, Cheng A, Ma C, Gao N, Zhao Y, Dai J, Zhao G. Proc Natl Acad Sci U S A 119 e2114445119 (2022)
  160. Exposure of intestinal explants to NX, but not to DON, enriches the secretome in mitochondrial proteins. Soler L, Miller I, Terciolo C, Hummel K, Nöbauer K, Neves M, Oswald IP. Arch Toxicol 96 2609-2619 (2022)
  161. Histone Methyltransferase MLL1 Mediates Oxidative Stress and Apoptosis upon Deoxynivalenol Exposure in the Intestinal Porcine Epithelial Cells. Shi D, Shan Y, Zhu X, Wang H, Wu S, Wu Z, Bao W. Antioxidants (Basel) 11 2006 (2022)
  162. Identification of Wheat LACCASEs in Response to Fusarium graminearum as Potential Deoxynivalenol Trappers. Sun Z, Zhou Y, Hu Y, Jiang N, Hu S, Li L, Li T. Front Plant Sci 13 832800 (2022)
  163. Mito-FUNCAT-FACS reveals cellular heterogeneity in mitochondrial translation. Kimura Y, Saito H, Osaki T, Ikegami Y, Wakigawa T, Ikeuchi Y, Iwasaki S. RNA 28 895-904 (2022)
  164. Paromomycin Reduces Vairimorpha (Nosema)ceranae Infection in Honey Bees but Perturbs Microbiome Levels and Midgut Cell Function. Cho RM, Kogan HV, Elikan AB, Snow JW. Microorganisms 10 1107 (2022)
  165. Potential anti-proliferative effects of chemical constituents and hemisynthetic derivatives from Scadoxus pseudocaulus (Amarillydaceae). Pagning ALN, Tamokou JD, Muhammad BT, Ngnokam D, AzefackTapondjou L, Ali MS, Hameed MW. Afr Health Sci 20 469-475 (2020)
  166. Semisynthetic blasticidin S ester derivatives show enhanced antibiotic activity. Gannett C, Banks P, Chuong C, Weger-Lucarelli J, Mevers E, Lowell AN. RSC Med Chem 14 782-789 (2023)
  167. Single-cell quantitative bioimaging of P. berghei liver stage translation. McLellan JL, Sausman W, Reers AB, Bunnik EM, Hanson KK. mSphere 8 e0054423 (2023)
  168. Structural biology: Ribosome revelations. Olivier NB. Nature 513 491-492 (2014)
  169. Studies of mutations of assembly factor Hit1 in budding yeast suggest translation defects as the molecular basis for PEHO syndrome. Dreggors-Walker RE, Cohen LN, Khoshnevis S, Marchand V, Motorin Y, Ghalei H. J Biol Chem 298 102261 (2022)
  170. Suppression of Trichothecene-Mediated Immune Response by the Fusarium Secondary Metabolite Butenolide in Human Colon Epithelial Cells. Woelflingseder L, Adam G, Marko D. Front Nutr 7 127 (2020)
  171. TIAR and FMRP shape pro-survival nascent proteome of leukemia cells in the bone marrow microenvironment. Wolczyk M, Serwa R, Kominek A, Klejman A, Milek J, Chwałek M, Turos-Korgul L, Charzyńska A, Dabrowski M, Dziembowska M, Skorski T, Piwocka K, Podszywalow-Bartnicka P. iScience 26 106543 (2023)
  172. The ribosome inhibitor chloramphenicol induces motility deficits in human spermatozoa: A proteomic approach identifies potentially involved proteins. Bisconti M, Leroy B, Gallagher MT, Senet C, Martinet B, Arcolia V, Wattiez R, Kirkman-Brown JC, Simon JF, Hennebert E. Front Cell Dev Biol 10 965076 (2022)
  173. rRNA expansion segment 7 in eukaryotes: from Signature Fold to tentacles. Biesiada M, Hu MY, Williams LD, Purzycka KJ, Petrov AS. Nucleic Acids Res 50 10717-10732 (2022)
  174. A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response. Subramanian A, Wang L, Moss T, Voorhies M, Sangwan S, Stevenson E, Pulido EH, Kwok S, Chalkley RJ, Li KH, Krogan NJ, Swaney DL, Burlingame AL, Floor SN, Sil A, Walter P, Mukherjee S. Nat Cell Biol 25 1600-1615 (2023)
  175. A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer. Terzo E, Apte SA, Padhye S, Rashed S, Austin W, Caponegro M, Reddy A, Shi S, Wang C, Clark RB, Sidransky D, Modur V, Badarinarayana V. Cancer Res Commun 3 969-979 (2023)
  176. ATAC and SAGA co-activator complexes utilize co-translational assembly, but their cellular localization properties and functions are distinct. Yayli G, Bernardini A, Mendoza Sanchez PK, Scheer E, Damilot M, Essabri K, Morlet B, Negroni L, Vincent SD, Timmers HTM, Tora L. Cell Rep 42 113099 (2023)
  177. Analysis of RIOK2 Functions in Mediating the Toxic Effects of Deoxynivalenol in Porcine Intestinal Epithelial Cells. Gao Z, Xu C, Fan H, Wang H, Wu Z, Wu S, Bao W. Int J Mol Sci 23 12712 (2022)
  178. Baited reconstruction with 2D template matching for high-resolution structure determination in vitro and in vivo without template bias. Lucas BA, Himes BA, Grigorieff N. Elife 12 RP90486 (2023)
  179. Competition for calnexin binding regulates secretion and turnover of misfolded GPI-anchored proteins. Cheatham AM, Sharma NR, Satpute-Krishnan P. J Cell Biol 222 e202108160 (2023)
  180. Concentration and time-dependent amyloidogenic characteristics of intrinsically disordered N-terminal region of Saccharomyces cerevisiae Stm1. Subbaiah S P V, Uttamrao PP, Das U, Sundaresan S, Rathinavelan T. Front Microbiol 14 1206945 (2023)
  181. Deep mutational analysis of elongation factor eEF2 residues implicated in human disease to identify functionally important contacts with the ribosome. Olson AN, Song S, Dinman JD. J Biol Chem 299 102771 (2023)
  182. Differential Paralog-Specific Expression of Multiple Small Subunit Proteins Cause Variations in Rpl42/eL42 Incorporation in Ribosome in Fission Yeast. Li W, Zhang J, Cheng W, Li Y, Feng J, Qin J, He X. Cells 11 2381 (2022)
  183. DrugPred_RNA-A Tool for Structure-Based Druggability Predictions for RNA Binding Sites. Rekand IH, Brenk R. J Chem Inf Model 61 4068-4081 (2021)
  184. Exposure to the mycotoxin deoxynivalenol reduces the transport of conjugated bile acids by intestinal Caco-2 cells. Wang J, Bakker W, Zheng W, de Haan L, Rietjens IMCM, Bouwmeester H. Arch Toxicol 96 1473-1482 (2022)
  185. Homeostatic regulation of ribosomal proteins by ubiquitin-independent cotranslational degradation. Ju D, Li L, Xie Y. Proc Natl Acad Sci U S A 120 e2306152120 (2023)
  186. In Vitro Assay of Translation Inhibition by Trichothecenes Using a Commercially Available System. Toyotome T, Kamei K. Toxins (Basel) 13 696 (2021)
  187. Influence of deoxynivalenol-contaminated feed on the immune response of pigs after PRRSV vaccination and infection. Pierron A, Vatzia E, Stadler M, Mair KH, Schmidt S, Stas MR, Dürlinger S, Kreutzmann H, Knecht C, Balka G, Lagler J, Zaruba M, Rümenapf T, Saalmüller A, Mayer E, Ladinig A, Gerner W. Arch Toxicol 97 1079-1089 (2023)
  188. Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis. Majumdar S, Emmerich A, Krakovka S, Mandava CS, Svärd SG, Sanyal S. Nucleic Acids Res 51 3436-3451 (2023)
  189. Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control. Ishimura R, Ito S, Mao G, Komatsu-Hirota S, Inada T, Noda NN, Komatsu M. Sci Adv 9 eadh3635 (2023)
  190. Near-Infrared MAO A Inhibitor (NMI) Outperformed FDA-Approved Chemotherapeutic Agents in Brain and Other Cancers: A Bioinformatic Analysis of NCI60 Screening Data. Feng Q, Lian Y, Qian Y, Shih JC. Brain Sci 11 1318 (2021)
  191. Nonsense mutation suppression is enhanced by targeting different stages of the protein synthesis process. Wittenstein A, Caspi M, Rippin I, Elroy-Stein O, Eldar-Finkelman H, Thoms S, Rosin-Arbesfeld R. PLoS Biol 21 e3002355 (2023)
  192. Pentahydroxyscirpene-Producing Strains, Formation In Planta, and Natural Occurrence. Varga E, Wiesenberger G, Fruhmann P, Malachová A, Svoboda T, Lemmens M, Adam G, Berthiller F. Toxins (Basel) 8 E295 (2016)
  193. Polyribosomes of circular topology are prevalent in mammalian cells. Baymukhametov TN, Lyabin DN, Chesnokov YM, Sorokin II, Pechnikova EV, Vasiliev AL, Afonina ZA. Nucleic Acids Res 51 908-918 (2023)
  194. Prognostic value of amino acid metabolism-related gene expression in invasive breast carcinoma. Wang Z, Guo X, Lian J, Ji Y, Li K. J Cancer Res Clin Oncol 149 11117-11133 (2023)
  195. Stress-induced nuclear speckle reorganization is linked to activation of immediate early gene splicing. Sung HM, Schott J, Boss P, Lehmann JA, Hardt MR, Lindner D, Messens J, Bogeski I, Ohler U, Stoecklin G. J Cell Biol 222 e202111151 (2023)
  196. Systematic Exploration of Functional Group Relevance for Anti-Leishmanial Activity of Anisomycin. Nguyen AMT, Shalev-Benami M, Rosa-Teijeiro C, Ibarra-Meneses AV, Yonath A, Bashan A, Jaffe CL, Olivier M, Fernandez-Prada C, Lubell WD. Biomedicines 11 2541 (2023)
  197. Two Onnamide Analogs from the Marine Sponge Theonella conica: Evaluation of Geometric Effects in the Polyene Systems on Biological Activity. Nakamura F, Kimura H, Fusetani N, Nakao Y. Molecules 28 2524 (2023)
  198. USP36 stabilizes nucleolar Snail1 to promote ribosome biogenesis and cancer cell survival upon ribotoxic stress. Qin K, Yu S, Liu Y, Guo R, Guo S, Fei J, Wang Y, Jia K, Xu Z, Chen H, Li F, Niu M, Dai MS, Dai L, Cao Y, Zhang Y, Xiao ZJ, Yi Y. Nat Commun 14 6473 (2023)
  199. Uncovering the Cellular Target of Agelastatin A. Park Y, Liau BB. Cell Chem Biol 24 542-543 (2017)
  200. [History of the Strasbourg Society of Biology]. Antony P, Romier C, Mantz JM. Biol Aujourdhui 211 117-125 (2017)


Quick links