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CK1d in complex with inhibitor

X-ray diffraction
2.41Å resolution
PDB entry 4tn6 coloured by chain, front view.
PDB entry 4tn6 coloured by chain, side view.
PDB entry 4tn6 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Casein kinase I isoform delta
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Multimeric state: monomeric
Accessible surface area: 14669.51 Å2
Buried surface area: 559.45 Å2
Dissociation area: 80.65 Å2
Dissociation energy (ΔGdiss): 12.26 kcal/mol
Dissociation entropy (TΔSdiss): 0.57 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155796
Assembly 2
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Assembly Name: Casein kinase I isoform delta
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Multimeric state: monomeric
Accessible surface area: 14123.3 Å2
Buried surface area: 766.96 Å2
Dissociation area: 83.85 Å2
Dissociation energy (ΔGdiss): 11.84 kcal/mol
Dissociation entropy (TΔSdiss): 0.59 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155796

Macromolecules

Casein kinase I isoform delta
Chains: A, B
Length: 318 amino acids
Theoretical weight: 36.66 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P48730 (Residues: 1-301; Coverage: 73%)
Gene names: CSNK1D, HCKID
Pfam: Protein kinase domain
InterPro:
CATH:
Casein kinase I isoform delta in PDB entry 4tn6, assembly 1, front view.
Casein kinase I isoform delta in PDB entry 4tn6, assembly 1, side view.
Casein kinase I isoform delta in PDB entry 4tn6, assembly 1, top view.
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