EC 2.3.2.24: (E3-independent) E2 ubiquitin-conjugating enzyme
Reaction catalysed:
(1a) S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [(E3-independent) E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-monoubiquitinyl-[(E3-independent) ubiquitin-conjugating enzyme]-L-cysteine
Systematic name:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:L-lysine ubiquitinyl transferase ([E3 ubiquitin transferase]-independent)
Alternative Name(s):
- E2-230K
- E3-independent ubiquitin-conjugating enzyme E2
- UBE2O
EC 2.3.2.27: RING-type E3 ubiquitin transferase
Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Systematic name:
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein]-L-lysine ubiquitin transferase (isopeptide bond-forming; RING-type)
Alternative Name(s):
- RING E3 ligase
- Ubiquitin transferase RING E3
EC 2.3.2.23: E2 ubiquitin-conjugating enzyme
Reaction catalysed:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine
Systematic name:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
Alternative Name(s):
- UBC
- Ubiquitin-carrier-protein E2
- Ubiquitin-conjugating enzyme E2
GO terms
Biochemical function:
Biological process:
- positive regulation of protein targeting to mitochondrion
- protein K6-linked ubiquitination
- protein K11-linked ubiquitination
- protein K48-linked ubiquitination
- protein autoubiquitination
- proteasome-mediated ubiquitin-dependent protein catabolic process
- protein modification process
- negative regulation of BMP signaling pathway
- protein ubiquitination
- DNA damage response
- apoptotic process
- protein monoubiquitination
- ubiquitin-dependent protein catabolic process
- DNA repair
- protein polyubiquitination
- negative regulation of transcription by RNA polymerase II
Protein families (Pfam)![The deposited structure of PDB entry 4s3o contains 2 copies of Pfam domain PF13923 (Zinc finger, C3HC4 type (RING finger)) in E3 ubiquitin-protein ligase RING2. Showing 1 copy in chain C [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/4s3o_2_B_Pfam_PF13923_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4s3o</span> contains 2 copies of Pfam domain <span class='highlight'>PF13923 (Zinc finger, C3HC4 type (RING finger))</span> in <span class='highlight'>E3 ubiquitin-protein ligase RING2</span>. Showing 1 copy in chain <span class='highlight'>C [auth B]</span>.")
![The deposited structure of PDB entry 4s3o contains 2 copies of Pfam domain PF13923 (Zinc finger, C3HC4 type (RING finger)) in Polycomb group RING finger protein 5. Showing 1 copy in chain E [auth C].](https://www.ebi.ac.uk/pdbe/static/entry/4s3o_3_C_Pfam_PF13923_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4s3o</span> contains 2 copies of Pfam domain <span class='highlight'>PF13923 (Zinc finger, C3HC4 type (RING finger))</span> in <span class='highlight'>Polycomb group RING finger protein 5</span>. Showing 1 copy in chain <span class='highlight'>E [auth C]</span>.")
InterPro annotations
CATH domains![The deposited structure of PDB entry 4s3o contains 2 copies of CATH domain 3.30.40.10 (Herpes Virus-1) in E3 ubiquitin-protein ligase RING2. Showing 1 copy in chain C [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/4s3o_2_B_CATH_3.30.40.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4s3o</span> contains 2 copies of CATH domain <span class='highlight'>3.30.40.10 (Herpes Virus-1)</span> in <span class='highlight'>E3 ubiquitin-protein ligase RING2</span>. Showing 1 copy in chain <span class='highlight'>C [auth B]</span>.")
![The deposited structure of PDB entry 4s3o contains 2 copies of CATH domain 3.30.40.10 (Herpes Virus-1) in Polycomb group RING finger protein 5. Showing 1 copy in chain E [auth C].](https://www.ebi.ac.uk/pdbe/static/entry/4s3o_3_C_CATH_3.30.40.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>4s3o</span> contains 2 copies of CATH domain <span class='highlight'>3.30.40.10 (Herpes Virus-1)</span> in <span class='highlight'>Polycomb group RING finger protein 5</span>. Showing 1 copy in chain <span class='highlight'>E [auth C]</span>.")
