› 4s1y

X-ray diffraction
3.16Å resolution

X-ray structure of human serum albumin complexed with cisplatin

Released:
DOI: 10.2210/pdb4s1y/pdb
PDB entry 4s1y coloured by chain, front view.
PDB entry 4s1y coloured by chain, side view.
PDB entry 4s1y coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cisplatin binding to human serum albumin: a structural study.
Ferraro G, Massai L, Messori L, Merlino A
Chem Commun (Camb) 51 9436-9 (2015)
PMID: 25873085

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136176 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chain: A
Molecule details ›
Chain: A
Length: 585 amino acids
Theoretical weight: 66.57 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P02768 (Residues: 25-609; Coverage: 99%)
Gene names: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

1 bound ligand:
Ligand CPT 5 x CPT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21
Unit cell:
a: 57.789Å b: 86.474Å c: 59.141Å
α: 90° β: 103.7° γ: 90°
R-values:
R R work R free
0.228 0.223 0.329
Expression system: Not provided

Quick links

Citations

3 review citations

The side effects of platinum-based chemotherapy drugs: a review for chemists.
Oun et al. (2018)
2 more