Structure analysis

Crystal Structure of the cobalt human insulin derivative

X-ray diffraction
1.73Å resolution
Source organism: Homo sapiens
Assemblies composition:
hetero dimer (preferred)
hetero dodecamer
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 3687.87 Å2
Buried surface area: 1776.2 Å2
Dissociation area: 847.49 Å2
Dissociation energy (ΔGdiss): 12.62 kcal/mol
Dissociation entropy (TΔSdiss): 8.18 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134182
Complex Portal ID: CPX-943
Assembly 2
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Multimeric state: hetero dimer
Accessible surface area: 3472.42 Å2
Buried surface area: 1914.5 Å2
Dissociation area: 915.44 Å2
Dissociation energy (ΔGdiss): 13.05 kcal/mol
Dissociation entropy (TΔSdiss): 8.16 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134182
Complex Portal ID: CPX-943
Assembly 3
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Multimeric state: hetero dodecamer
Accessible surface area: 12018.64 Å2
Buried surface area: 20049.62 Å2
Dissociation area: 193.17 Å2
Dissociation energy (ΔGdiss): 26.04 kcal/mol
Dissociation entropy (TΔSdiss): 0.02 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-134235

Macromolecules

Chains: A, C
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
InterPro:

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Chains: B, D
Length: 30 amino acids
Theoretical weight: 3.43 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 25-54; Coverage: 35%)
Gene name: INS
Pfam: Insulin/IGF/Relaxin family
InterPro:

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