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Crystal structure of Human galectin-3 CRD in complex with lactose (pH 7.5, PEG6000)

X-ray diffraction
2Å resolution
PDB entry 4rl7 coloured by chain, front view.
PDB entry 4rl7 coloured by chain, side view.
PDB entry 4rl7 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Galectin-3
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Multimeric state: monomeric
Accessible surface area: 7149.03 Å2
Buried surface area: 598.59 Å2
Dissociation area: 237.24 Å2
Dissociation energy (ΔGdiss): -3.22 kcal/mol
Dissociation entropy (TΔSdiss): 4.19 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148215

Macromolecules

Galectin-3
Chain: A
Length: 144 amino acids
Theoretical weight: 16.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P17931 (Residues: 111-250; Coverage: 56%)
Gene names: LGALS3, MAC2
Pfam: Galactoside-binding lectin
InterPro:
CATH: Jelly Rolls
Galectin-3 in PDB entry 4rl7, assembly 1, front view.
Galectin-3 in PDB entry 4rl7, assembly 1, side view.
Galectin-3 in PDB entry 4rl7, assembly 1, top view.
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