Function and Biology

Crystal structure of the non-phosphorylated human alpha1 beta2 gamma1 holo-AMPK complex

Source organism: Homo sapiens
Biochemical function: ATP binding
Biological process: cellular response to nutrient levels
Cellular component: nucleotide-activated protein kinase complex

EC 2.7.11.31: [Hydroxymethylglutaryl-CoA reductase (NADPH)] kinase

Reaction catalysed:
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
Systematic name:
ATP:[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphotransferase
Alternative Name(s):
  • 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase
  • 3-hydroxy-3-methylglutaryl-CoA reductase kinase
  • AMP-activated protein kinase
  • AMPK
  • Beta-hydroxy-beta-methylglutaryl-CoA reductase kinase
  • HMG-CoA reductase kinase
  • Hydroxymethylglutaryl coenzyme A reductase kinase
  • Hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating)
  • Hydroxymethylglutaryl-CoA reductase kinase
  • Reductase kinase
  • STK29
  • [Hydroxymethylglutaryl-CoA reductase (NADPH(2))] kinase

EC 2.7.11.26: [Tau protein] kinase

Reaction catalysed:
ATP + [tau protein] = ADP + [tau protein] phosphate
Systematic name:
ATP:[tau-protein] O-phosphotransferase
Alternative Name(s):
  • ATP:tau-protein O-phosphotransferase
  • Brain protein kinase PK40erk
  • CDK5/p23
  • Cdk5/p20
  • GSK
  • Glycogen synthase kinase-3-beta
  • Protein tau kinase
  • STK31
  • TPK
  • TPK I
  • TPK II
  • TTK
  • Tau kinase
  • Tau-protein kinase I
  • Tau-protein kinase II
  • Tau-tubulin kinase
  • [Tau-protein] kinase

EC 2.7.11.1: Non-specific serine/threonine protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
  • A-kinase
  • AP50 kinase
  • ATP-protein transphosphorylase
  • Beta-IIPKC
  • Beta-adrenergic receptor kinase
  • CK-2
  • CKI
  • CKII
  • Calcium-dependent protein kinase C
  • Calcium/phospholipid-dependent protein kinase
  • Casein kinase
  • Casein kinase (phosphorylating)
  • Casein kinase 2
  • Casein kinase I
  • Casein kinase II
  • Cyclic AMP-dependent protein kinase
  • Cyclic AMP-dependent protein kinase A
  • Cyclic monophosphate-dependent protein kinase
  • Cyclic nucleotide-dependent protein kinase
  • Cyclin-dependent kinase
  • Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
  • Dsk1
  • Epsilon PKC
  • Glycogen synthase A kinase
  • Glycogen synthase a kinase
  • Glycogen synthase kinase
  • HIPK2
  • Hpr kinase
  • Hydroxyalkyl-protein kinase
  • M phase-specific cdc2 kinase
  • MAPK
  • Mitogen-activated S6 kinase
  • Mitogen-activated protein kinase
  • P82 kinase
  • PKA
  • PKC
  • Phosphorylase B kinase kinase
  • Phosphorylase b kinase kinase
  • Phosphorylase b kinase kinase
  • Protein glutamyl kinase
  • Protein kinase (phosphorylating)
  • Protein kinase A
  • Protein kinase CK2
  • Protein kinase p58
  • Protein phosphokinase
  • Protein serine kinase
  • Protein serine-threonine kinase
  • Protein-aspartyl kinase
  • Protein-cysteine kinase
  • Protein-serine kinase
  • Prp4 protein kinase
  • Raf kinase
  • Raf-1
  • Ribosomal S6 protein kinase
  • Ribosomal protein S6 kinase II
  • STK32
  • Serine kinase
  • Serine protein kinase
  • Serine(threonine) protein kinase
  • Serine-specific protein kinase
  • Serine/threonine protein kinase
  • T-antigen kinase
  • Threonine-specific protein kinase
  • Twitchin kinase
  • Type-2 casein kinase
  • WEE1Hu
  • Wee 1-like kinase
  • Wee-kinase
  • cAMP-dependent protein kinase
  • cAMP-dependent protein kinase A
  • cGMP-dependent protein kinase

Sequence families

Pfam Protein families (Pfam)
PF00571
Domain description: CBS domain
Occurring in:
  1. 5'-AMP-activated protein kinase subunit gamma-1
The deposited structure of PDB entry 4rew contains 4 copies of Pfam domain PF00571 (CBS domain) in 5'-AMP-activated protein kinase subunit gamma-1. Showing 4 copies in chain C [auth G].

PF04739
Domain description: 5'-AMP-activated protein kinase beta subunit, interaction domain
Occurring in:
  1. 5'-AMP-activated protein kinase subunit beta-2
The deposited structure of PDB entry 4rew contains 1 copy of Pfam domain PF04739 (5'-AMP-activated protein kinase beta subunit, interaction domain) in 5'-AMP-activated protein kinase subunit beta-2. Showing 1 copy in chain B.

PF16561
Domain description: Glycogen recognition site of AMP-activated protein kinase
Occurring in:
  1. 5'-AMP-activated protein kinase subunit beta-2
The deposited structure of PDB entry 4rew contains 1 copy of Pfam domain PF16561 (Glycogen recognition site of AMP-activated protein kinase) in 5'-AMP-activated protein kinase subunit beta-2. Showing 1 copy in chain B (this domain is out of the observed residue ranges!).

PF16579
Domain description: Adenylate sensor of SNF1-like protein kinase
Occurring in:
  1. 5'-AMP-activated protein kinase catalytic subunit alpha-1
The deposited structure of PDB entry 4rew contains 1 copy of Pfam domain PF16579 (Adenylate sensor of SNF1-like protein kinase) in 5'-AMP-activated protein kinase catalytic subunit alpha-1. Showing 1 copy in chain A.

PF21147
Domain description: AMP-activated protein kinase, alpha subunit, autoinhibitory domain
Occurring in:
  1. 5'-AMP-activated protein kinase catalytic subunit alpha-1
The deposited structure of PDB entry 4rew contains 1 copy of Pfam domain PF21147 (AMP-activated protein kinase, alpha subunit, autoinhibitory domain) in 5'-AMP-activated protein kinase catalytic subunit alpha-1. Showing 1 copy in chain A.

PF00069
Domain description: Protein kinase domain
Occurring in:
  1. 5'-AMP-activated protein kinase catalytic subunit alpha-1
The deposited structure of PDB entry 4rew contains 1 copy of Pfam domain PF00069 (Protein kinase domain) in 5'-AMP-activated protein kinase catalytic subunit alpha-1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000644
Domain description: CBS domain
Occurring in:
  1. 5'-AMP-activated protein kinase subunit gamma-1
IPR046342
Domain description: CBS domain superfamily
Occurring in:
  1. 5'-AMP-activated protein kinase subunit gamma-1
IPR006828
Domain description: Association with the SNF1 complex (ASC) domain
Occurring in:
  1. 5'-AMP-activated protein kinase subunit beta-2
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. 5'-AMP-activated protein kinase catalytic subunit alpha-1
IPR037256
Domain description: ASC domain superfamily
Occurring in:
  1. 5'-AMP-activated protein kinase subunit beta-2
IPR032640
Domain description: AMP-activated protein kinase, glycogen-binding domain
Occurring in:
  1. 5'-AMP-activated protein kinase subunit beta-2
IPR014756
Domain description: Immunoglobulin E-set
Occurring in:
  1. 5'-AMP-activated protein kinase subunit beta-2
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. 5'-AMP-activated protein kinase subunit beta-2
IPR028375
Domain description: KA1 domain/Ssp2, C-terminal
Occurring in:
  1. 5'-AMP-activated protein kinase catalytic subunit alpha-1
IPR032270
Domain description: AMPK, C-terminal adenylate sensor domain
Occurring in:
  1. 5'-AMP-activated protein kinase catalytic subunit alpha-1
IPR039137
Domain description: 5'-AMP-activated protein kinase alpha 1 catalytic subunit, C-terminal
Occurring in:
  1. 5'-AMP-activated protein kinase catalytic subunit alpha-1
IPR028797
Domain description: PRKAA1, UBA-like autoinhibitory domain
Occurring in:
  1. 5'-AMP-activated protein kinase catalytic subunit alpha-1
IPR008271
Domain description: Serine/threonine-protein kinase, active site
Occurring in:
  1. 5'-AMP-activated protein kinase catalytic subunit alpha-1
IPR017441
Domain description: Protein kinase, ATP binding site
Occurring in:
  1. 5'-AMP-activated protein kinase catalytic subunit alpha-1
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. 5'-AMP-activated protein kinase catalytic subunit alpha-1