› 4raf

X-ray diffraction
2Å resolution

Crystal structure of PP2Ca-D38A

Released:
DOI: 10.2210/pdb4raf/pdb
PDB entry 4raf coloured by chain, front view.
PDB entry 4raf coloured by chain, side view.
PDB entry 4raf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The catalytic role of the M2 metal ion in PP2Cα.
Pan C, Tang JY, Xu YF, Xiao P, Liu HD, Wang HA, Wang WB, Meng FG, Yu X, Sun JP
Sci Rep 5 8560 (2015)
PMID: 25708299

Function and Biology Details

Reaction catalysed: 
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153029 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein phosphatase 1A Chain: A
Molecule details ›
Chain: A
Length: 367 amino acids
Theoretical weight: 40.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35813 (Residues: 2-368; Coverage: 96%)
Gene names: PPM1A, PPPM1A
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand MN 1 x MN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P3121
Unit cell:
a: 91.262Å b: 91.262Å c: 105.767Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.196 0.194 0.222
Expression system: Escherichia coli

Quick links

Citations

14 citation in other articles

UIS2: A Unique Phosphatase Required for the Development of Plasmodium Liver Stages.
Zhang et al. (2016)
13 more

1 mention without citation

Deciphering the molecular components of the quorum sensing system in the fungus Ophiostoma piceae.
Santos-Pascual et al. (2023)