› 4qy4

X-ray diffraction
1.97Å resolution

Crystal structure of the bromodomain of human SMARCA2

Released:
DOI: 10.2210/pdb4qy4/pdb
PDB entry 4qy4 coloured by chain, front view.
PDB entry 4qy4 coloured by chain, side view.
PDB entry 4qy4 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tallant C, Savitsky P, Nunez-Alonso G, Fonseca M, Krojer T, Filippakopoulos P, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156349 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Probable global transcription activator SNF2L2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 123 amino acids
Theoretical weight: 14.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51531 (Residues: 1373-1511; Coverage: 8%)
Gene names: BAF190B, BRM, SMARCA2, SNF2A, SNF2L2
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
Ligand ZN 3 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P31
Unit cell:
a: 64.346Å b: 64.346Å c: 89.117Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.226 0.224 0.279
Expression system: Escherichia coli

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