› 4q41

X-ray diffraction
2.2Å resolution

Crystal structure of Schistosoma mansoni arginase in complex with L-lysine

Released:
DOI: 10.2210/pdb4q41/pdb
PDB entry 4q41 coloured by chain, front view.
PDB entry 4q41 coloured by chain, side view.
PDB entry 4q41 coloured by chain, top view.
Source organism: Schistosoma mansoni
Primary publication:
Crystal structure of Schistosoma mansoni arginase, a potential drug target for the treatment of schistosomiasis.
Hai Y, Edwards JE, Van Zandt MC, Hoffmann KF, Christianson DW
Biochemistry 53 4671-84 (2014)
PMID: 25007099

Function and Biology Details

Reaction catalysed: 
L-arginine + H(2)O = L-ornithine + urea
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180507 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Arginase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 385 amino acids
Theoretical weight: 42.27 KDa
Source organism: Schistosoma mansoni
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q6WVP6 (Residues: 1-364; Coverage: 100%)
Sequence domains: Arginase family
Structure domains: Ureohydrolase domain

Ligands and Environments

3 bound ligands:
Ligand MN 8 x MN
Ligand LYS 2 x LYS
Ligand GOL 6 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P213
Unit cell:
a: 177.448Å b: 177.448Å c: 177.448Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.173 0.172 0.201
Expression system: Escherichia coli BL21(DE3)

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Citations

3 review citations

Arginase Inhibitors: A Rational Approach Over One Century.
Pudlo et al. (2017)
2 more

1 mention without citation

Crystal structure of Schistosoma mansoni arginase, a potential drug target for the treatment of schistosomiasis.
Hai et al. (2014)