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Crystal structure of histone acetyltransferase complex

Source organisms:
Biochemical function: histone binding
Biological process: subtelomeric heterochromatin formation
Cellular component: nucleus

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EC 2.3.1.48: Histone acetyltransferase

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Systematic name:
Acetyl-CoA:[protein]-L-lysine acetyltransferase
Alternative Name(s):
  • Acetyl-CoA:histone acetyltransferase
  • Histone acetokinase
  • Histone acetylase
  • Histone transacetylase
  • Lysine acetyltransferase
  • Nucleosome-histone acetyltransferase
  • Protein lysine acetyltransferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00400
Domain description: WD domain, G-beta repeat
Occurring in:
  1. Histone acetyltransferase type B subunit 2
The deposited structure of PDB entry 4psw contains 1 copy of Pfam domain PF00400 (WD domain, G-beta repeat) in Histone acetyltransferase type B subunit 2. Showing 1 copy in chain B.

PF12265
Domain description: Histone-binding protein RBBP4 or subunit C of CAF1 complex
Occurring in:
  1. Histone acetyltransferase type B subunit 2
The deposited structure of PDB entry 4psw contains 1 copy of Pfam domain PF12265 (Histone-binding protein RBBP4 or subunit C of CAF1 complex) in Histone acetyltransferase type B subunit 2. Showing 1 copy in chain B.

PF21184
Domain description: Fungal HAT1, C-terminal
Occurring in:
  1. Histone acetyltransferase type B catalytic subunit

PF00583
Domain description: Acetyltransferase (GNAT) family
Occurring in:
  1. Histone acetyltransferase type B catalytic subunit
The deposited structure of PDB entry 4psw contains 1 copy of Pfam domain PF00583 (Acetyltransferase (GNAT) family) in Histone acetyltransferase type B catalytic subunit. Showing 1 copy in chain A.

PF10394
Domain description: Histone acetyl transferase HAT1 N-terminus
Occurring in:
  1. Histone acetyltransferase type B catalytic subunit
The deposited structure of PDB entry 4psw contains 1 copy of Pfam domain PF10394 (Histone acetyl transferase HAT1 N-terminus) in Histone acetyltransferase type B catalytic subunit. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001680
Domain description: WD40 repeat
Occurring in:
  1. Histone acetyltransferase type B subunit 2
IPR001951
Domain description: Histone H4
Occurring in:
  1. Histone H4
IPR009072
Domain description: Histone-fold
Occurring in:
  1. Histone H4
IPR019775
Domain description: WD40 repeat, conserved site
Occurring in:
  1. Histone acetyltransferase type B subunit 2
IPR000182
Domain description: GNAT domain
Occurring in:
  1. Histone acetyltransferase type B catalytic subunit
IPR017380
Domain description: Histone acetyltransferase type B, catalytic subunit
Occurring in:
  1. Histone acetyltransferase type B catalytic subunit
IPR019809
Domain description: Histone H4, conserved site
Occurring in:
  1. Histone H4
IPR036322
Domain description: WD40-repeat-containing domain superfamily
Occurring in:
  1. Histone acetyltransferase type B subunit 2
IPR022052
Domain description: Histone-binding protein RBBP4, N-terminal
Occurring in:
  1. Histone acetyltransferase type B subunit 2
IPR015943
Domain description: WD40/YVTN repeat-like-containing domain superfamily
Occurring in:
  1. Histone acetyltransferase type B subunit 2
IPR013523
Domain description: Histone acetyltransferase HAT1, C-terminal
Occurring in:
  1. Histone acetyltransferase type B catalytic subunit
IPR037113
Domain description: Histone acetyl transferase 1, N-terminal domain superfamily
Occurring in:
  1. Histone acetyltransferase type B catalytic subunit
IPR019467
Domain description: Histone acetyl transferase HAT1 N-terminal
Occurring in:
  1. Histone acetyltransferase type B catalytic subunit
IPR016181
Domain description: Acyl-CoA N-acyltransferase
Occurring in:
  1. Histone acetyltransferase type B catalytic subunit

Structure domains

CATH CATH domains
3.40.630.30
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aminopeptidase
Homology: Aminopeptidase
Occurring in:
  1. Histone acetyltransferase type B catalytic subunit
The deposited structure of PDB entry 4psw contains 1 copy of CATH domain 3.40.630.30 (Aminopeptidase) in Histone acetyltransferase type B catalytic subunit. Showing 1 copy in chain A.
3.90.360.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Histone Acetyltransferase; domain 1
Homology: Histone acetyl transferase 1 (HAT1), N-terminal domain
Occurring in:
  1. Histone acetyltransferase type B catalytic subunit
The deposited structure of PDB entry 4psw contains 1 copy of CATH domain 3.90.360.10 (Histone Acetyltransferase; domain 1) in Histone acetyltransferase type B catalytic subunit. Showing 1 copy in chain A.
2.130.10.10
Class: Mainly Beta
Architecture: 7 Propeller
Topology: Methylamine Dehydrogenase; Chain H
Homology: YVTN repeat-like/Quinoprotein amine dehydrogenase
Occurring in:
  1. Histone acetyltransferase type B subunit 2
The deposited structure of PDB entry 4psw contains 1 copy of CATH domain 2.130.10.10 (Methylamine Dehydrogenase; Chain H) in Histone acetyltransferase type B subunit 2. Showing 1 copy in chain B.
1.10.10.390
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: Arc Repressor Mutant, subunit A
Occurring in:
  1. Histone acetyltransferase type B catalytic subunit
The deposited structure of PDB entry 4psw contains 1 copy of CATH domain 1.10.10.390 (Arc Repressor Mutant, subunit A) in Histone acetyltransferase type B catalytic subunit. Showing 1 copy in chain A.

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