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Medium chain acyl-CoA dehydrogenase, K304E mutant

X-ray diffraction
1.73Å resolution
PDB entry 4p13 coloured by chain, front view.
PDB entry 4p13 coloured by chain, side view.
PDB entry 4p13 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
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Multimeric state: homo tetramer
Accessible surface area: 50851.43 Å2
Buried surface area: 23822.24 Å2
Dissociation area: 4,859.62 Å2
Dissociation energy (ΔGdiss): 74.69 kcal/mol
Dissociation entropy (TΔSdiss): 16.29 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-145791

Macromolecules

Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
Chains: A, B, C, D
Length: 387 amino acids
Theoretical weight: 42.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11310 (Residues: 35-421; Coverage: 92%)
Gene name: ACADM
Pfam:
InterPro:
CATH:
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial in PDB entry 4p13, assembly 1, front view.
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial in PDB entry 4p13, assembly 1, side view.
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial in PDB entry 4p13, assembly 1, top view.
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