Function and Biology

Crystal Structure Analysis of Macrophage Migration Inhibitory Factor in complex with N-[(4-cyanophenyl)methyl]methanethioamide

Source organism: Homo sapiens
Biochemical function: isomerase activity
Biological process: positive regulation of phosphorylation
Cellular component: vesicle

EC 5.3.3.12: L-dopachrome isomerase

Reaction catalysed:
L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.
Comments:
  • Stereospecific for L-dopachrome (5,6-dioxo-2,3-5,6-tetrahydroindole- 2-carboxylate).
  • Dopachrome methyl ester is a substrate, but dopaminochrome (2,3- dihydroxyindolyl-5,6-quinone) is not (see also EC 4.1.1.84).
Systematic name:
L-dopachrome keto-enol isomerase
Alternative Name(s):
  • DCF
  • DCT
  • Dopachrome Delta-isomerase
  • Dopachrome Delta(7),Delta(2)-isomerase
  • Dopachrome conversion factor
  • Dopachrome oxidoreductase
  • Dopachrome tautomerase
  • Dopachrome-rearranging enzyme
  • Tyrosinase-related protein 2
  • Dopachrome rearranging enzyme
  • TRP-1
  • TRP2
  • TRP-2
  • Tryosinase-related protein-2
  • Dopachrome isomerase
  • Dopachrome keto-enol isomerase
  • L-dopachrome-methyl ester tautomerase
  • TRP

EC 5.3.2.1: Phenylpyruvate tautomerase

Reaction catalysed:
Keto-phenylpyruvate = enol-phenylpyruvate.
Comments:
  • Also acts on other arylpyruvates.
Systematic name:
Phenylpyruvate keto--enol-isomerase
Alternative Name(s):
  • Phenylpyruvic keto--enol isomerase
  • Phenylpyruvate keto--enol tautomerase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF01187
Domain description: Macrophage migration inhibitory factor (MIF)
Occurring in:
  1. Macrophage migration inhibitory factor
1 copy of Pfam domain PF01187 (Macrophage migration inhibitory factor (MIF)) in Macrophage migration inhibitory factor in PDB 4p01.

InterPro InterPro annotations
IPR001398
Domain description: Macrophage migration inhibitory factor
Occurring in:
  1. Macrophage migration inhibitory factor
IPR014347
Domain description: Tautomerase/MIF superfamily
Occurring in:
  1. Macrophage migration inhibitory factor
IPR019829
Domain description: Macrophage migration inhibitory factor, conserved site
Occurring in:
  1. Macrophage migration inhibitory factor

Structure domain

CATH CATH domain
3.30.429.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Macrophage Migration Inhibitory Factor
Homology: Macrophage Migration Inhibitory Factor
Occurring in:
  1. Macrophage migration inhibitory factor
1 copy of CATH domain 3.30.429.10 (Macrophage Migration Inhibitory Factor) in Macrophage migration inhibitory factor in PDB 4p01.