Structure analysis

Crystal Structure Analysis of Macrophage Migration Inhibitory Factor in complex with N-[(4-cyanophenyl)methyl]methanethioamide

X-ray diffraction
2.07Å resolution
Source organism: Homo sapiens
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo trimer
Accessible surface area: 12400 Å2
Buried surface area: 8300 Å2
Dissociation area: 3,300 Å2
Dissociation energy (ΔGdiss): 46 kcal/mol
Dissociation entropy (TΔSdiss): 24 kcal/mol
Interface energy (ΔGint): -82 kcal/mol
Symmetry number: 3

Macromolecules

Chains: A, B, C
Length: 114 amino acids
Theoretical weight: 12.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P14174 (Residues: 2-115; Coverage: 99%)
Gene names: GLIF, MIF, MMIF
Pfam: Macrophage migration inhibitory factor (MIF)
InterPro:
CATH: Macrophage Migration Inhibitory Factor

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