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Crystal structure of human calcineurin

Source organism: Homo sapiens
Biochemical function: metal ion binding
Biological process: negative regulation of calcium ion import across plasma membrane
Cellular component: glutamatergic synapse

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EC 3.1.3.16: Protein-serine/threonine phosphatase

Reaction catalysed:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Systematic name:
Phosphoprotein phosphohydrolase
Alternative Name(s):
  • 3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase
  • Aspergillus awamori acid protein phosphatase
  • BCKDH phosphatase
  • Branched-chain alpha-keto acid dehydrogenase phosphatase
  • Calcineurin
  • Casein phosphatase
  • HMG-CoA reductase phosphatase
  • Phosphatase 2A
  • Phosphatase 2B
  • Phosphatase C-II
  • Phosphatase H-II
  • Phosphatase I
  • Phosphatase IB
  • Phosphatase II
  • Phosphatase III
  • Phosphatase IV
  • Phosphatase SP
  • Phosphoprotein phosphatase
  • Phosphopyruvate dehydrogenase phosphatase
  • Phosphospectrin phosphatase
  • Polycation modulated (PCM-) phosphatase
  • Protein D phosphatase
  • Protein phosphatase
  • Protein phosphatase-1
  • Protein phosphatase-2A
  • Protein phosphatase-2B
  • Protein phosphatase-2C
  • Serine/threonine specific protein phosphatase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF13499
Domain description: EF-hand domain pair
Occurring in:
  1. Calcineurin subunit B type 1
The deposited structure of PDB entry 4or9 contains 2 copies of Pfam domain PF13499 (EF-hand domain pair) in Calcineurin subunit B type 1. Showing 2 copies in chain B.

PF00149
Domain description: Calcineurin-like phosphoesterase
Occurring in:
  1. Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
The deposited structure of PDB entry 4or9 contains 1 copy of Pfam domain PF00149 (Calcineurin-like phosphoesterase) in Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002048
Domain description: EF-hand domain
Occurring in:
  1. Calcineurin subunit B type 1
IPR006186
Domain description: Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Occurring in:
  1. Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
IPR018247
Domain description: EF-Hand 1, calcium-binding site
Occurring in:
  1. Calcineurin subunit B type 1
IPR029052
Domain description: Metallo-dependent phosphatase-like
Occurring in:
  1. Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
IPR011992
Domain description: EF-hand domain pair
Occurring in:
  1. Calcineurin subunit B type 1
IPR015757
Domain description: Calcineurin B protein
Occurring in:
  1. Calcineurin subunit B type 1
IPR004843
Domain description: Calcineurin-like phosphoesterase domain, ApaH type
Occurring in:
  1. Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
IPR041751
Domain description: PP2B, metallophosphatase domain
Occurring in:
  1. Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
IPR043360
Domain description: PP2B
Occurring in:
  1. Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

Structure domains

CATH CATH domains
1.10.238.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Recoverin; domain 1
Homology: EF-hand
Occurring in:
  1. Calcineurin subunit B type 1
The deposited structure of PDB entry 4or9 contains 1 copy of CATH domain 1.10.238.10 (Recoverin; domain 1) in Calcineurin subunit B type 1. Showing 1 copy in chain B.
3.60.21.10
Class: Alpha Beta
Architecture: 4-Layer Sandwich
Topology: Purple Acid Phosphatase; chain A, domain 2
Homology: Purple Acid Phosphatase; chain A, domain 2
Occurring in:
  1. Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
The deposited structure of PDB entry 4or9 contains 1 copy of CATH domain 3.60.21.10 (Purple Acid Phosphatase; chain A, domain 2) in Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform. Showing 1 copy in chain A.

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